SERUM AND SALIVA COLLAGENASE-3 (MMP-13) IN PATIENTS WITH ORAL LICHEN PLANUS AND ORAL SQUAMOUS CELL CARCINOMA

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AGHA HOSSEINI FARZANEH; MIRZAII DIZGAH IRAJ

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Journal Paper

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Journal: Medical Journal of The Islamic Republic of Iran Year:2015 | Volume:29 | Issue:1 Page(s): 0-0

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Information Journal Paper

Title

SERUM AND SALIVA COLLAGENASE-3 (MMP-13) IN PATIENTS WITH ORAL LICHEN PLANUS AND ORAL SQUAMOUS CELL CARCINOMA

Author(s)

AGHA HOSSEINI FARZANEH | MIRZAII DIZGAH IRAJ | Issue Writer Certificate

Keywords

MMP-13

ORAL LICHEN PLANUS

SQUAMOUS CELL CARCINOMA

SALIVA

Abstract

Background: ORAL LICHEN PLANUS (OLP) has been classified as a pre-malignant condition. Matrix metalloproteinase-13 (MMP-13) or collagenase-3 may play a key role in cancer development. The aim of this study was to compare serum and SALIVA MMP-13 between patients with ORAL LICHEN PLANUS (OLP) and oral SQUAMOUS CELL CARCINOMA (OSCC).Methods: This cross sectional study was performed on 30 patients with OLP (8 reticular and 22 erosive forms) and 20 patients with OSCC (6 in low stage and 14 in advanced stage) who were selected randomly. The study was conducted at the Cancer Department, Clinic of Oral Medicine, Tehran University of Medical Sciences. The serum and SALIVA MMP-13 were assayed by ELISA method.Statistical analysis of the Student’s t-test, ANOVA and Pearson correlation coefficient was performed.Results: There were no significant differences in mean SALIVA and serum levels of MMP-13 between patients with OSCC and OLP and their subgroups. Serum MMP-13 correlated significantly with unstimulated (r=0.307, p=0.048), but not with stimulated, SALIVA MMP-13.Conclusion: Serum and SALIVA MMP-13 levels appear to be statistically similar in OLP and OSCC.

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APA: Copy

AGHA HOSSEINI, FARZANEH, & MIRZAII DIZGAH, IRAJ. (2015). SERUM AND SALIVA COLLAGENASE-3 (MMP-13) IN PATIENTS WITH ORAL LICHEN PLANUS AND ORAL SQUAMOUS CELL CARCINOMA. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 29(1), 0-0. SID. https://sid.ir/paper/294706/en

Vancouver: Copy

AGHA HOSSEINI FARZANEH, MIRZAII DIZGAH IRAJ. SERUM AND SALIVA COLLAGENASE-3 (MMP-13) IN PATIENTS WITH ORAL LICHEN PLANUS AND ORAL SQUAMOUS CELL CARCINOMA. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2015;29(1):0-0. Available from: https://sid.ir/paper/294706/en

IEEE: Copy

FARZANEH AGHA HOSSEINI, and IRAJ MIRZAII DIZGAH, “SERUM AND SALIVA COLLAGENASE-3 (MMP-13) IN PATIENTS WITH ORAL LICHEN PLANUS AND ORAL SQUAMOUS CELL CARCINOMA,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 29, no. 1, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/294706/en

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