The effect of hormone therapy on bone mineral density and cardiovascular factors among Iranian female athletes with amenorrhea/oligomenorrhea: A randomized clinical trial

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DADGOSTAR HALEH; SOLEIMANY GHAZALEH; MOVASEGHI SHAFIEH; DADGOSTAR ELHAM; LOTFIAN SARA

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Journal Paper

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Journal: Medical Journal of The Islamic Republic of Iran Year:2018 | Volume:32 | Issue:1 Page(s): 0-0

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Title

The effect of hormone therapy on bone mineral density and cardiovascular factors among Iranian female athletes with amenorrhea/oligomenorrhea: A randomized clinical trial

Author(s)

Keywords

Functional hypothalamic menstrual disorder (FHMD)

Hypoestrogenism

Bone density

Cardiovascular risk factor

Hormone therapy

OCP (oral contraceptive pills)

Abstract

Background: Functional hypothalamic menstrual disorder (FHMD) has a destructive effect on the athlete’ s bone mineral density and cardiovascular system. Utilizing hormone replacement therapy to treat FHMD in athletes is controversial. This study was conducted to examine the effect of Hormone therapy on Bone density and the cardiovascular system of professional female athletes with FHMD. Methods: In this study, 18 female athletes with at least a 2-year history of FHMD were recruited in a 9-month single blind randomized clinical intervention (RCT) and randomly classified into 2 groups: the oral contraceptive pills (OCP) group, who received a lowdose combined oral contraceptive (OC) containing 30 μ g ethinyl estradiol and 150 μ g levonorgestrel (n= 10), and the control group (n = 8). Bone mineral densitometry (BMD) and certain Cardiovascular risk factors were measured before and after the 9-month trial. The Chi square test was used to compare the quantitative and qualitative results. Results: Bone mineral density did not change significantly in either group. Very low density lipoprotein (VLDL) (p= 0. 035) and Apolipoprotein B (Apo B) (p= 0. 04) reduced significantly in the OCP group. An increase was observed in the serum levels of Apolipoprotein A (Apo A) (p= 0. 01) in the control group. Changes in the Apo B to Apo A ratio was significant in both groups (OCP group: p= 0. 018, control group: p= 0. 040). No significant changes were observed in the other measured factors. Conclusion: Although the administration of estrogen did not significantly increase bone mineral density, it had positive effects on the cardiovascular system and lipid profile.

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APA: Copy

DADGOSTAR, HALEH, SOLEIMANY, GHAZALEH, MOVASEGHI, SHAFIEH, DADGOSTAR, ELHAM, & LOTFIAN, SARA. (2018). The effect of hormone therapy on bone mineral density and cardiovascular factors among Iranian female athletes with amenorrhea/oligomenorrhea: A randomized clinical trial. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 32(1), 0-0. SID. https://sid.ir/paper/294916/en

Vancouver: Copy

DADGOSTAR HALEH, SOLEIMANY GHAZALEH, MOVASEGHI SHAFIEH, DADGOSTAR ELHAM, LOTFIAN SARA. The effect of hormone therapy on bone mineral density and cardiovascular factors among Iranian female athletes with amenorrhea/oligomenorrhea: A randomized clinical trial. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2018;32(1):0-0. Available from: https://sid.ir/paper/294916/en

IEEE: Copy

HALEH DADGOSTAR, GHAZALEH SOLEIMANY, SHAFIEH MOVASEGHI, ELHAM DADGOSTAR, and SARA LOTFIAN, “The effect of hormone therapy on bone mineral density and cardiovascular factors among Iranian female athletes with amenorrhea/oligomenorrhea: A randomized clinical trial,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 32, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/294916/en

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