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Title

The relationship between embb306 and embb406 mutations and ethambutol resistant in Mycobacterium tuberculosis isolated from patiens in west of Iran

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Abstract

 Background: Mutations in embB gene have been reported in ethambutol (EMB) resistance Mycobacterium tuberculosis (M. tuberculosis) isolates. The aim of this study was survey on embB 306 and 406 EMB resistant M. tuberculosis isolated from patients in West of Iran (2014-2015). Methods: Fifty strains of M. tuberculosis from patients with pulmonary tuberculosis (TB) were considered. Drug susceptibility using proportional method was performed. Polymerase chain reaction (PCR)-DNA sequencing was applied for mutation in embB 306 and 406 codon detection. Data were analyzed in SPSS 16 software using descriptive statistics and Fisher's exact test (p<0. 05). Results: In this study 7 (14%) M. tuberculosis isolates were resistant to EMB. 6 (85. 71%) and 1 (14. 28%) resistant isolates had embB 306 and 304 codon Mutations, respectively. Between embB306 Mutations and resistance to EMB and MDR isolates had a significant relationship (p<0. 001). Conclusion: The data indicated that embB 306 Mutations have effect on EMB resistant. Detection of EMB resistant and these Mutations prominent for antibiotic prescription.

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    APA: Copy

    MOHAMMADI, BAHMAN, MOHAJERI, PARVIZ, ROUHI, SAMANEH, & RAMAZANZADEH, RASHID. (2018). The relationship between embb306 and embb406 mutations and ethambutol resistant in Mycobacterium tuberculosis isolated from patiens in west of Iran. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 32(1), 0-0. SID. https://sid.ir/paper/294922/en

    Vancouver: Copy

    MOHAMMADI BAHMAN, MOHAJERI PARVIZ, ROUHI SAMANEH, RAMAZANZADEH RASHID. The relationship between embb306 and embb406 mutations and ethambutol resistant in Mycobacterium tuberculosis isolated from patiens in west of Iran. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2018;32(1):0-0. Available from: https://sid.ir/paper/294922/en

    IEEE: Copy

    BAHMAN MOHAMMADI, PARVIZ MOHAJERI, SAMANEH ROUHI, and RASHID RAMAZANZADEH, “The relationship between embb306 and embb406 mutations and ethambutol resistant in Mycobacterium tuberculosis isolated from patiens in west of Iran,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 32, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/294922/en

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