مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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1

Information Journal Paper

Title

Dkk-3 as a potential biomarker for diagnosis and prognosis of colorectal cancer

Pages

  0-0

Abstract

 Background: The Dickkopf 3 (Dkk-3) protein is a member of the Dkk family known as Wnt signaling inhibitor. The level of Dkk-3 changes in a wide range of cancers, such as Colorectal cancer, lung cancer, prostate cancer, and bladder cancer, is proposed as a Biomarker for diagnosis and prognosis of many cancers. The present study was conducted to evaluate the serum level of Dkk-3 as a cancer Biomarker and to determine their prognostic value in Colorectal cancer (CRC) patients and healthy matched controls. Methods: A total of 30 Colorectal cancer patients at different stages of the disease and healthy matched controls with no history of inflammatory and autoimmune disease or cancer were enrolled in the study. The level of Dkk-3 was assessed serologically using enzymelinked immunosorbent assay (ELISA) method, moreover, relevance of these markers with patients’ clinicopathological features was subsequently assessed. Means comparison and ROC curves analysis were done using SPSS software. P-value ˂ 0. 05 was considered significant in all the tests. Results: In this study, it was revealed that serum level of Dkk-3 was significantly (p<0. 001) lower in patients compared to the healthy controls. Statistical analysis showed that serum level of Dkk-3 has 78% specificity and 77% sensitivity (AUC= 0. 782, 95% CI) for diagnosis of Colorectal cancer. Conclusion: Dkk-3 protein can be considered as a potential Biomarker for diagnosis and possibly the prognosis of Colorectal cancer.

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    • Cite

    APA: Copy

    SAFARI, ELAHE, MOSAYEBI, GHASEM, & KHORRAMI, SAMANEH. (2018). Dkk-3 as a potential biomarker for diagnosis and prognosis of colorectal cancer. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 32(1), 0-0. SID. https://sid.ir/paper/294981/en

    Vancouver: Copy

    SAFARI ELAHE, MOSAYEBI GHASEM, KHORRAMI SAMANEH. Dkk-3 as a potential biomarker for diagnosis and prognosis of colorectal cancer. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2018;32(1):0-0. Available from: https://sid.ir/paper/294981/en

    IEEE: Copy

    ELAHE SAFARI, GHASEM MOSAYEBI, and SAMANEH KHORRAMI, “Dkk-3 as a potential biomarker for diagnosis and prognosis of colorectal cancer,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 32, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/294981/en

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