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Information Journal Paper

Title

Investigation of adherent-invasive E. coli in patients with Crohn's disease

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Abstract

 Background: Crohn's disease and Ulcerative colitis are known as Inflammatory bowel disease with high morbidity which are as a result of increasing immune responses to intestinal microbiota in genetically susceptible individuals. The association of adherent invasive Escherichia coli with Crohn's disease in human has been discussed for decades. The principal aim of this study was to assess the relationship between adherent invasive Escherichia coli in Iranian patients with Crohn's disease. Methods: The presence of adherent invasive Escherichia coli DNA and viable adherent invasive Escherichia coli cells were identified through PCR and conventional culture methods, respectively. All the specimens were subsequently cultured in Hi Chrome Agar medium. Results: Using molecular assay, the invasive plasmid antigen H and invasion-association locus genes were detected from tissue samples confirming the presence of adherent-invasive Escherichia coli. The invasive plasmid antigen H was detected in 46. 7% of CD and 13. 3% of healthy peoples. The invasion-association locus gene was found in 36. 7% of patients with Crohn's disease and 10% in individuals without IBD. Conclusion: This study demonstrated an increased frequency of adherent invasive E. coli with invasive plasmid antigen H and invasion-association locus genes from patients with CD in comparison to control individuals. Moreover, it was shown that adherent invasive E. coli with the invasive plasmid antigen H and invasion-association locus genes can act as a predisposing factor in the development of IBD.

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    APA: Copy

    Sarabi Asiabar, Akram, ASADZADEH AGHDAEI, HAMID, SABOKBAR, AZAR, ZALI, MOHAMMAD REZA, & FEIZABADI, MOHAMMAD MEHDI. (2018). Investigation of adherent-invasive E. coli in patients with Crohn's disease. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 32(1), 0-0. SID. https://sid.ir/paper/294986/en

    Vancouver: Copy

    Sarabi Asiabar Akram, ASADZADEH AGHDAEI HAMID, SABOKBAR AZAR, ZALI MOHAMMAD REZA, FEIZABADI MOHAMMAD MEHDI. Investigation of adherent-invasive E. coli in patients with Crohn's disease. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2018;32(1):0-0. Available from: https://sid.ir/paper/294986/en

    IEEE: Copy

    Akram Sarabi Asiabar, HAMID ASADZADEH AGHDAEI, AZAR SABOKBAR, MOHAMMAD REZA ZALI, and MOHAMMAD MEHDI FEIZABADI, “Investigation of adherent-invasive E. coli in patients with Crohn's disease,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 32, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/294986/en

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