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Information Journal Paper

Title

Effects of vitamin D optimization on quality of life of patients with fibromyalgia: A randomized controlled trial

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Abstract

 Background: Numerous studies have been conducted to evaluate the frequency of hypovitaminosis D in patients with Fibromyalgia syndrome (FMS) and its association with FMS symptoms. This study aimed at assessing the effect of hypovitaminosis D on the symptoms and Quality of life of patients with fibromyalgia. Methods: A total of 74 FMS patients with hypovitaminosis D were randomly assigned into group A (Trazodone 25 mg at bedtime + Vitamin D 50 000 IU weekly) and group B (Trazodone 25 mg at bedtime + placebo). Serum Vitamin D level, Widespread Pain Index (WPI), Fibromyalgia Impact Questionnaire (FIQ), Pittsburgh Sleep Quality Index (PSQI), and Short Form Health Survey (SF-36) were used at the beginning of the treatment and 4 and 8 weeks post treatment. Results: Significant improvements were observed in WPI, FIQ, and PSQI scores in both groups. Moreover, combination of Vitamin D and Trazodone resulted in significant improvement of SF-36 scores compared to Trazodone therapy. Improvement in Pain-related indices including the WPI and the physical component score (PCS) fraction of SF-36 was more noticeable in Vitamin D/Trazodone combination therapy. Conclusion: This study suggests that Vitamin D supplementation has significant therapeutic benefits in the management of FMS, especially in Pain reduction of patients with fibromyalgia. According to our results, a combination of Vitamin D supplements and a conventional antidepressant, when given to Vitamin D-deficient fibromyalgia patients, could significantly improve both physical and psychological symptoms.

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    APA: Copy

    MIRZAEI, ALIREZA, ZABIHIYEGANEH, MOZHDEH, JAHED, SEYED ADEL, Khiabani, Elnaz, & NOJOMI, MARZIEH. (2018). Effects of vitamin D optimization on quality of life of patients with fibromyalgia: A randomized controlled trial. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 32(1), 0-0. SID. https://sid.ir/paper/294999/en

    Vancouver: Copy

    MIRZAEI ALIREZA, ZABIHIYEGANEH MOZHDEH, JAHED SEYED ADEL, Khiabani Elnaz, NOJOMI MARZIEH. Effects of vitamin D optimization on quality of life of patients with fibromyalgia: A randomized controlled trial. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2018;32(1):0-0. Available from: https://sid.ir/paper/294999/en

    IEEE: Copy

    ALIREZA MIRZAEI, MOZHDEH ZABIHIYEGANEH, SEYED ADEL JAHED, Elnaz Khiabani, and MARZIEH NOJOMI, “Effects of vitamin D optimization on quality of life of patients with fibromyalgia: A randomized controlled trial,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 32, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/294999/en

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