Outcome of treatment with EMA/EP (etoposide methotrexate and actinomycin-D/ etoposide and cisplatin) regimen in gestational trophoblastic neoplasia

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AMINIMOGHADDAM SOHEILA; Nezhadisalami Forough; ANJIDANI SHABNAM; Barzin Tond Saeedeh

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Medical Journal of The Islamic Republic of Iran Year:2018 | Volume:32 | Issue:1 Page(s): 0-0

Download Full-Text

View:

282

Download:

Cites:

Information Journal Paper

Title

Outcome of treatment with EMA/EP (etoposide methotrexate and actinomycin-D/ etoposide and cisplatin) regimen in gestational trophoblastic neoplasia

Author(s)

AMINIMOGHADDAM SOHEILA | Nezhadisalami Forough | ANJIDANI SHABNAM | Barzin Tond Saeedeh | Issue Writer Certificate

Keywords

EMA/EP regimen

Chemotherapy

Gestational trophoblastic neoplasia

Abstract

Background: Gestational trophoblastic neoplasia (GTN) originates from placental trophoblast and is a highly chemosensitive and curable gynecologic malignancy. The present study was conducted to evaluate the effectiveness and safety of EMA/EP (etoposide, methotrexate, actinomycin-D, etoposide, and cisplatin) regimen in the treatment of high-risk GTN as well as patients’ outcome. Methods: Hospital charts of all patients with confirmed diagnosis of high-risk GTN who received EMA/EP regimen treatment during a 12-year period (2001-2012) at the tertiary center of comprehensive women's hospital in Tehran, Iran, were reviewed from 2012 to 2013, retrospectively. Results: In this study, 25 patients with GTN who were treated with EMA/EP regimen during the study were identified. Complete remission rate in GTN patients with failure of single agent Chemotherapy who were treated with EMA/EP regimen, as the first-line treatment, was 100%, while it was 81% in those with primary high-risk GTN. Overall remission rate in high-risk GTN patients treated with EMA/EP regimen was 88%. Anemia (92%) and leucopenia (72%) were the most common adverse effects of EMA/EP Chemotherapy regimen. Acute myeloid leukemia (AML) and mortality, as the most severe adverse effects of EMA/EP regimen, were seen only in 1 patient. Conclusion: According to the results, EMA/EP regimen could induce complete remission in 88% of patients with high-risk GTN. Application of EMA/EP is recommended as the first-line therapy in patients with failure of single agent Chemotherapy. However, proper care should be considered to prevent and reduce EMA/EP hematologic toxicity.

Cites

No record.

References

Cite

APA: Copy

AMINIMOGHADDAM, SOHEILA, Nezhadisalami, Forough, ANJIDANI, SHABNAM, & Barzin Tond, Saeedeh. (2018). Outcome of treatment with EMA/EP (etoposide methotrexate and actinomycin-D/ etoposide and cisplatin) regimen in gestational trophoblastic neoplasia. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 32(1), 0-0. SID. https://sid.ir/paper/295033/en

Vancouver: Copy

AMINIMOGHADDAM SOHEILA, Nezhadisalami Forough, ANJIDANI SHABNAM, Barzin Tond Saeedeh. Outcome of treatment with EMA/EP (etoposide methotrexate and actinomycin-D/ etoposide and cisplatin) regimen in gestational trophoblastic neoplasia. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2018;32(1):0-0. Available from: https://sid.ir/paper/295033/en

IEEE: Copy

SOHEILA AMINIMOGHADDAM, Forough Nezhadisalami, SHABNAM ANJIDANI, and Saeedeh Barzin Tond, “Outcome of treatment with EMA/EP (etoposide methotrexate and actinomycin-D/ etoposide and cisplatin) regimen in gestational trophoblastic neoplasia,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 32, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/295033/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops