HUMAN SPERM DNA DAMAGE IN THE CONTEXT OF ASSISTED REPRODUCTIVE TECHNIQUES

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YOUSSRY M.; ORIEF Y.; OZMEN B.; AL HASANI S.; ZOHNI KH.

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Journal Paper

Paper Information

Journal: International Journal of Reproductive BioMedicine Year:2007 | Volume:5 | Issue:4 Page(s): 137-150

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Title

HUMAN SPERM DNA DAMAGE IN THE CONTEXT OF ASSISTED REPRODUCTIVE TECHNIQUES

Author(s)

Keywords

FERTILIZATION

SPERM DNA DAMAGE

ASSISTED REPRODUCTIVE TECHNIQUE (ART)

Abstract

FERTILIZATION involves direct interaction of the sperm and oocyte, fusion of the cell membranes and union of male and female gamete genomes. The completion of this process and subsequent embryo development depend in part on the inherent integrity of the sperm DNA. Sperm genome quality has been emphasized for several years as playing a major role in early embryogenesis. There is clinical evidence showing that human SPERM DNA DAMAGE may adversely affect reproductive outcomes and that spermatozoa of infertile men possess substantially more DNA damage than do spermatozoa of fertile men. Testing DNA integrity may help selecting spermatozoa with intact DNA or with the least amount of DNA damage for use in assisted reproductive techniques (ARTs). This review will focus on how sperm DNA is organized, what causes SPERM DNA DAMAGE and what impact this damage may have on reproductive outcome.

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APA: Copy

YOUSSRY, M., ORIEF, Y., OZMEN, B., AL HASANI, S., & ZOHNI, KH.. (2007). HUMAN SPERM DNA DAMAGE IN THE CONTEXT OF ASSISTED REPRODUCTIVE TECHNIQUES. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 5(4), 137-150. SID. https://sid.ir/paper/295136/en

Vancouver: Copy

YOUSSRY M., ORIEF Y., OZMEN B., AL HASANI S., ZOHNI KH.. HUMAN SPERM DNA DAMAGE IN THE CONTEXT OF ASSISTED REPRODUCTIVE TECHNIQUES. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2007;5(4):137-150. Available from: https://sid.ir/paper/295136/en

IEEE: Copy

M. YOUSSRY, Y. ORIEF, B. OZMEN, S. AL HASANI, and KH. ZOHNI, “HUMAN SPERM DNA DAMAGE IN THE CONTEXT OF ASSISTED REPRODUCTIVE TECHNIQUES,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 5, no. 4, pp. 137–150, 2007, [Online]. Available: https://sid.ir/paper/295136/en

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