TOXICOLOGICAL EFFECTS OF AMITRIPTYLINE ON SEX HORMONE LEVEL OF MALE RATS

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BAHMANPOUR S.; KHOSHNOUD M.J.; KAZEROUNI H.; NAMAVAR M.R.; BASTI A.

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Journal Paper

Paper Information

Journal: International Journal of Reproductive BioMedicine Year:2009 | Volume:7 | Issue:SUPPL 1 Page(s): 0-0

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Title

TOXICOLOGICAL EFFECTS OF AMITRIPTYLINE ON SEX HORMONE LEVEL OF MALE RATS

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Keywords

AMITRIPTYLINE

ANTIDEPRESSANTS DRUGS

REPRODUCTIVE SYSTEM

SEX HORMONE

Abstract

Introduction: The antidepressants are among the drugs, which cause toxic effects on much of organ system especially male REPRODUCTIVE SYSTEM. About 15% of these drugs have adverse effects on hormonal levels and target organs like testes that secret hormones and produces male germ cells during spermatogenesis. Studies showed that the effects of antidepressant on sexual dysfunction are more than 60%. Effects of drugs on sexual dysfunction and spermatogenesis appear to be due to changes in hormones level such as testetorone, LH, FSH, prolactine and estrogen. The aim of this study was to evaluate the toxicological effects of AMITRIPTYLINE on SEX HORMONE and the sexual dysfunction results of this toxicity.Materials and Methods: In this study 60 mature male Sprague Dawley rats were used and standard laboratory conditions were done during experiment. The rats were divided into four groups, 3 groups were treated with 5, 10 and 25 mg/kg of AMITRIPTYLINE for 30 days intraperitoneally and the untreated group was said to be control. After 30 days of treatment, the animals were sacrificed and the blood was collected and centrifuged for hormonal assay.Results: The results of the study showed that the AMITRIPTYLINE doses have different effects on hormonal levels. The higher dose (25 mg/kg) decreased the testosterone and prolactine levels but increased the FSH levels. AMITRIPTYLINE changes the hormonal levels and disrupts the testosterone and estrogen ratio also.Conclusion: It can be concluded that the toxic effects of the AMITRIPTYLINE caused the disruption of SEX HORMONE and can leads to sexual dysfunction and infertility.

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