COMPARISON OF CELL MEDIATED IMMUNITY IN MANIC PHASE PATIENTS (BIPOLAR I) WITH NORMAL SUBJECTS

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HAMIDI KENARI A.; NOURBALA A.A.

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Journal: Hakim Journal Year:2004 | Volume:6 | Issue:4 Page(s): 35-41

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Title

COMPARISON OF CELL MEDIATED IMMUNITY IN MANIC PHASE PATIENTS (BIPOLAR I) WITH NORMAL SUBJECTS

Author(s)

HAMIDI KENARI A. | NOURBALA A.A. | Issue Writer Certificate

Keywords

BIPOLAR I DISORDERQ4

MANIAQ4

CELLULAR IMMUNITYQ4

Abstract

Introduction: Relationship between psychiatric disorder and immune system has been the center of interest among researchers for years. Recent findings concerning the impairment of immunity in depressed patients has provided valuable clues for further research and understanding the multiple aspects of psychiatric disorders. But, there is almost lack of evidence about immunity in bipolar disorders. In this study, our aim was to evaluate the immune system of patients with BIPOLAR I DISORDER (during manic episode) compared with normal subjects.Methods: Twenty-four manic patients (15 male, 9 female) and 26 normal subjects (15 male, 11 female) aged 15-50 were clinically interviewed by authors and underwent the study. At entry (before treatment with lithium and haloprideol) a blood sample was taken from all subjects and the function status of CELLULAR IMMUNITY was evaluated by measuring lymphocyte transformation test (LTT) against PHA Mitogen and indices of T cell function including: CD4, CD8, CD3 and CD4/CD8 ratio as well as CD56; an index of natural killer cells. The measurement was repeated for all subjects 2 months, after clinical remission of patients.Results: T- test and Levene’s test showed a significant difference between patients and control subjects in LTT but not in other indices. The proliferation of the patients’ lymphocytes was lower in comparison to the subject group, but regarding variables such as CD4, CD8, CD3, CD4/CD8, CD56 there was no significant difference.Conclusion: The results are an evidence for impairment in cellular immune system of bipolar I patients (manic phase) and show that the proliferation of immune cells against mitogen was lower than the control group but it needs more research about this issue.

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APA: Copy

HAMIDI KENARI, A., & NOURBALA, A.A.. (2004). COMPARISON OF CELL MEDIATED IMMUNITY IN MANIC PHASE PATIENTS (BIPOLAR I) WITH NORMAL SUBJECTS. HAKIM RESEARCH JOURNAL, 6(4), 35-41. SID. https://sid.ir/paper/29534/en

Vancouver: Copy

HAMIDI KENARI A., NOURBALA A.A.. COMPARISON OF CELL MEDIATED IMMUNITY IN MANIC PHASE PATIENTS (BIPOLAR I) WITH NORMAL SUBJECTS. HAKIM RESEARCH JOURNAL[Internet]. 2004;6(4):35-41. Available from: https://sid.ir/paper/29534/en

IEEE: Copy

A. HAMIDI KENARI, and A.A. NOURBALA, “COMPARISON OF CELL MEDIATED IMMUNITY IN MANIC PHASE PATIENTS (BIPOLAR I) WITH NORMAL SUBJECTS,” HAKIM RESEARCH JOURNAL, vol. 6, no. 4, pp. 35–41, 2004, [Online]. Available: https://sid.ir/paper/29534/en

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