INDUCTION OF PROTECTIVE ANTIBODY RESPONSE BY RECOMBINANT HEPATITIS B VACCINE AMONG HEALTHY NEONATES IN THE CITY OF KERMAN

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JAFARZADEH A.; SHOKRI F.

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Journal: HAKIM RESEARCH JOURNAL Year:2001 | Volume:3 | Issue:4 Page(s): 282-288

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Title

INDUCTION OF PROTECTIVE ANTIBODY RESPONSE BY RECOMBINANT HEPATITIS B VACCINE AMONG HEALTHY NEONATES IN THE CITY OF KERMAN

Author(s)

JAFARZADEH A. | SHOKRI F. | Issue Writer Certificate

Keywords

VACCINATIONQ4

HEPATITIS B VACCINEQ4

ANTI - HBS ANTIBODYQ4

LMMUNOGENICITYQ4

Abstract

Lack of protective antibody response to HEPATITIS B VACCINE has bem reported in 1-10% of healthy neonates worldwide. In the present study triple doses of 10 µg recombinant HEPATITIS B VACCINE was administered at 0, 1.5 and 9 months intervals to a group of healthy neonates in the city of Kerman. ANTI - HBS ANTIBODY was then measured in-serum collected 2-4 weeks after completion of primary VACCINATION by sandwich ELlSA using commercial kits.Our results show that protective antibody response (anti - HBs>10 IU/L) was developed in 96.1% of vaccines. However, 3.9% of the neonates did not develop protective response. The responders were arbitrary classified into low (anti- HBs = 10-100 IU/L; x= 41 IU/L), intermediate (anti – HBs=100-1000 IU/L; x= 238 IU/L) and high responders (anti - HBs>1000 IU/L; x= 8900 IU/L). Accordingly 10%, 18.2% and 68% of the vaccines were found to be low, intermediate and high responders, respectively. Responsiveness to the vaccine was similarly represented in both male and female vaccinees. These results suggest high immunogenicity of this vaccine in healthy Iranian neonates.

Cites

THE FACTORS INFLUENCING THE IMMUNE RESPONSE TO HEPATITIS B VACCINE AND PERSISTENCE OF THE PROTECTION

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APA: Copy

JAFARZADEH, A., & SHOKRI, F.. (2001). INDUCTION OF PROTECTIVE ANTIBODY RESPONSE BY RECOMBINANT HEPATITIS B VACCINE AMONG HEALTHY NEONATES IN THE CITY OF KERMAN. HAKIM RESEARCH JOURNAL, 3(4), 282-288. SID. https://sid.ir/paper/29558/en

Vancouver: Copy

JAFARZADEH A., SHOKRI F.. INDUCTION OF PROTECTIVE ANTIBODY RESPONSE BY RECOMBINANT HEPATITIS B VACCINE AMONG HEALTHY NEONATES IN THE CITY OF KERMAN. HAKIM RESEARCH JOURNAL[Internet]. 2001;3(4):282-288. Available from: https://sid.ir/paper/29558/en

IEEE: Copy

A. JAFARZADEH, and F. SHOKRI, “INDUCTION OF PROTECTIVE ANTIBODY RESPONSE BY RECOMBINANT HEPATITIS B VACCINE AMONG HEALTHY NEONATES IN THE CITY OF KERMAN,” HAKIM RESEARCH JOURNAL, vol. 3, no. 4, pp. 282–288, 2001, [Online]. Available: https://sid.ir/paper/29558/en

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