SCREENING OF Y-CHROMOSOME MICRODELETION IN IRANIAN INFERTILE MEN

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KALANTAR S.M.; DEHGHANI M.; ZAIMY A.; SOLEIMANIAN S.

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Journal Paper

Paper Information

Journal: International Journal of Reproductive BioMedicine Year:2011 | Volume:9 | Issue:SUPPL 2 Page(s): 61-61

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Title

SCREENING OF Y-CHROMOSOME MICRODELETION IN IRANIAN INFERTILE MEN

Author(s)

KALANTAR S.M. | DEHGHANI M. | ZAIMY A. | SOLEIMANIAN S. | Issue Writer Certificate

Keywords

Y-CHROMOSOME MICRODELETION

MALE INFERTILITY

AZOOSPERMIA FACTORS

Abstract

Introduction: It has been hypothesized that Y-q microdeletion can account for significant proportion of infertility in men.There are three nonoverlapping regions referred to as the "azoospermia factors" AZFa, AZFb, and AZFc from proximal to distal Y-q. These have been defined as spermatogenesis loci, this region deletions have been shown to be involved in male azoospermic or severe oligoozospermic infertility.Aims: Evaluation the rate of Y-CHROMOSOME MICRODELETION in men with infertility.Materials and Methods: Ninety infertile men were selected; all of patients were azoospermic or oligoozospermic. DNA extraction and chromosomal analysis were done on blood sample, blood lymphocyte were selected for genomic DNA extraction. Sequence Tagged Site-Polymerase Chain Reaction (STS-PCR) method was done to identify the presence of microdeletion in AZFa, AZFb or AZFc loci.Ten STS primers that include two controls were selected to determine Y-CHROMOSOME MICRODELETIONs.Results: 8.8% (8.90) of all patients have at least one microdeletion in AZF loci. Totally 15 microdeletions was observed, one case had deletions in three AZF regions, five cases had deletion in two AZF regions and finally two cases in one region. The rate of deletions was 46% (7/15) for AZFc, 33% (5/15) for AZFa and 20% (3/15) for AZFb.Conclusion: Y-CHROMOSOME MICRODELETION could be related to MALE INFERTILITY.

Cites

FREQUENCY OF Y CHROMOSOME MICRO DELETIONS AMONG IRANIAN INFERTILE MEN WITH AZOOSPERMIA AND SEVERE OLIGOZOOSPERMIA: A META-ANALYSIS

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APA: Copy

KALANTAR, S.M., DEHGHANI, M., ZAIMY, A., & SOLEIMANIAN, S.. (2011). SCREENING OF Y-CHROMOSOME MICRODELETION IN IRANIAN INFERTILE MEN. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 9(SUPPL 2), 61-61. SID. https://sid.ir/paper/295801/en

Vancouver: Copy

KALANTAR S.M., DEHGHANI M., ZAIMY A., SOLEIMANIAN S.. SCREENING OF Y-CHROMOSOME MICRODELETION IN IRANIAN INFERTILE MEN. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2011;9(SUPPL 2):61-61. Available from: https://sid.ir/paper/295801/en

IEEE: Copy

S.M. KALANTAR, M. DEHGHANI, A. ZAIMY, and S. SOLEIMANIAN, “SCREENING OF Y-CHROMOSOME MICRODELETION IN IRANIAN INFERTILE MEN,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 9, no. SUPPL 2, pp. 61–61, 2011, [Online]. Available: https://sid.ir/paper/295801/en

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