THE EFFECTS OF CALCITRIOL ON IMPROVEMENT OF INSULIN RESISTANCE, OVULATION AND COMPARISON WITH METFORMIN THERAPY IN PCOS PATIENTS: A RANDOMIZED PLACEBO- CONTROLLED CLINICAL TRIAL

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BONAKDARAN SHOKOUFEH; MAZLOOM KHORASANI ZAHRA; DAVACHI BEHROOZ; MAZLOOM KHORASANI JAVAD

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Journal Paper

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Journal: International Journal of Reproductive BioMedicine Year:2012 | Volume:10 | Issue:5 Page(s): 465-472

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Title

THE EFFECTS OF CALCITRIOL ON IMPROVEMENT OF INSULIN RESISTANCE, OVULATION AND COMPARISON WITH METFORMIN THERAPY IN PCOS PATIENTS: A RANDOMIZED PLACEBO- CONTROLLED CLINICAL TRIAL

Author(s)

BONAKDARAN SHOKOUFEH | MAZLOOM KHORASANI ZAHRA | DAVACHI BEHROOZ | MAZLOOM KHORASANI JAVAD | Issue Writer Certificate

Keywords

PCOS

OVULATION

VITAMIN D

INSULIN RESISTANCE

Abstract

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females of reproductive age. INSULIN RESISTANCE is a frequent metabolic disturbance in PCOS. VITAMIN D deficiency is a common problem. Accumulating evidence suggests that VITAMIN D has a role on insulin sensitivity so may contribute to reduction of hyperandrogenemia.Objective: The aim was to determine the effects of VITAMIN D treatment in metabolic components and OVULATION evidence in PCOS.Materials and Methods: Fifty one untreated PCOS patients were randomly divided into three groups and treated with calcitriol, metformin, or placebo. Before and 3 months after treatment, OVULATION evidence was assessed by ovarian trans abdominal sonography. Plasma fasting glucose, insulin, homeostasis model assessment INSULIN RESISTANCE (HOMA-IR), 25-hydroxyvitamin D, parathyroid hormone and androgen levels were measured before and after treatment. A 75gr glucose test was performed before and after treatment and two set of results was compared.Results: Three patients did not continue this study. Only 11 patient (22.9%) had sufficient VITAMIN D levels (>30 ng/ml). Metformin caused a significant decrease in weight (p=0.027), insulin level (p=0.043), and INSULIN RESISTANCE (p=0.048). Systolic blood pressure and PTH significantly improved after calcitriol (p=0.029, p=0.009 respectively). An improvement in OVULATION was detected after calcitriol and seven patients, without evidence of OVULATION before treatment, illustrated OVULATION after 3 months. Difference with calcitriol in OVULATION was significant versus other two methods (p=0.02).Conclusion: Calcitriol treatment in PCOS may be prior to metformin in OVULATION induction.

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APA: Copy

BONAKDARAN, SHOKOUFEH, MAZLOOM KHORASANI, ZAHRA, DAVACHI, BEHROOZ, & MAZLOOM KHORASANI, JAVAD. (2012). THE EFFECTS OF CALCITRIOL ON IMPROVEMENT OF INSULIN RESISTANCE, OVULATION AND COMPARISON WITH METFORMIN THERAPY IN PCOS PATIENTS: A RANDOMIZED PLACEBO- CONTROLLED CLINICAL TRIAL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 10(5), 465-472. SID. https://sid.ir/paper/295922/en

Vancouver: Copy

BONAKDARAN SHOKOUFEH, MAZLOOM KHORASANI ZAHRA, DAVACHI BEHROOZ, MAZLOOM KHORASANI JAVAD. THE EFFECTS OF CALCITRIOL ON IMPROVEMENT OF INSULIN RESISTANCE, OVULATION AND COMPARISON WITH METFORMIN THERAPY IN PCOS PATIENTS: A RANDOMIZED PLACEBO- CONTROLLED CLINICAL TRIAL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2012;10(5):465-472. Available from: https://sid.ir/paper/295922/en

IEEE: Copy

SHOKOUFEH BONAKDARAN, ZAHRA MAZLOOM KHORASANI, BEHROOZ DAVACHI, and JAVAD MAZLOOM KHORASANI, “THE EFFECTS OF CALCITRIOL ON IMPROVEMENT OF INSULIN RESISTANCE, OVULATION AND COMPARISON WITH METFORMIN THERAPY IN PCOS PATIENTS: A RANDOMIZED PLACEBO- CONTROLLED CLINICAL TRIAL,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 10, no. 5, pp. 465–472, 2012, [Online]. Available: https://sid.ir/paper/295922/en

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