CASE CONTROL STUDY OF THE FACTOR V LEIDEN AND FACTOR II G20210A MUTATION FREQUENCY IN WOMEN WITH RECURRENT PREGNANCY LOSS

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TEREMMAHI ARDESTANI MAJID; NODUSHAN HOSSEIN HADI; AFLATOONIAN ABBAS; GHASEMI NASRIN; SHEIKHHA MOHAMMAD HASAN

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Journal: International Journal of Reproductive BioMedicine Year:2013 | Volume:11 | Issue:1 Page(s): 61-64

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Title

CASE CONTROL STUDY OF THE FACTOR V LEIDEN AND FACTOR II G20210A MUTATION FREQUENCY IN WOMEN WITH RECURRENT PREGNANCY LOSS

Author(s)

Keywords

FACTOR V LEIDEN

FACTOR II G20210A MUTATION

RECURRENT ABORTION

Abstract

Background: Recurrent pregnancy loss (RPL) caused by various genetic and non-genetic factors. After chromosome abnormality, thrombophilia is one of the most important genetic factors that could cause RPL. FACTOR V LEIDEN and FACTOR II G20210A MUTATION were the most common mutations cause thrombophilia in the world.Objective: The purpose of this study was to determine the frequency of FACTOR V LEIDEN and prothrombine gene mutations in women with RPL compared with women who had uneventful pregnancies.Materials and Methods: This case control study evaluates the frequency of factor V-Leiden and factor II G20210 genotypes in 80 women with two or more pregnancy losses, compared with 80 women without adverse pregnancy outcome. The mutations were assessed by PCR-RFLP.Results: Frequency of the FACTOR V LEIDEN among cases was 2.5%, which was higher than controls (1.25%), but the difference was not significant (p<0.05). No factor II G20210 mutation was found among cases and controls.Conclusion: These data did not confirm that FACTOR V LEIDEN and factor II G20210 mutation might play a role in recurrent pregnancy loss in Iranian women.

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APA: Copy

TEREMMAHI ARDESTANI, MAJID, NODUSHAN, HOSSEIN HADI, AFLATOONIAN, ABBAS, GHASEMI, NASRIN, & SHEIKHHA, MOHAMMAD HASAN. (2013). CASE CONTROL STUDY OF THE FACTOR V LEIDEN AND FACTOR II G20210A MUTATION FREQUENCY IN WOMEN WITH RECURRENT PREGNANCY LOSS. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 11(1), 61-64. SID. https://sid.ir/paper/295945/en

Vancouver: Copy

TEREMMAHI ARDESTANI MAJID, NODUSHAN HOSSEIN HADI, AFLATOONIAN ABBAS, GHASEMI NASRIN, SHEIKHHA MOHAMMAD HASAN. CASE CONTROL STUDY OF THE FACTOR V LEIDEN AND FACTOR II G20210A MUTATION FREQUENCY IN WOMEN WITH RECURRENT PREGNANCY LOSS. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2013;11(1):61-64. Available from: https://sid.ir/paper/295945/en

IEEE: Copy

MAJID TEREMMAHI ARDESTANI, HOSSEIN HADI NODUSHAN, ABBAS AFLATOONIAN, NASRIN GHASEMI, and MOHAMMAD HASAN SHEIKHHA, “CASE CONTROL STUDY OF THE FACTOR V LEIDEN AND FACTOR II G20210A MUTATION FREQUENCY IN WOMEN WITH RECURRENT PREGNANCY LOSS,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 11, no. 1, pp. 61–64, 2013, [Online]. Available: https://sid.ir/paper/295945/en

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