THE STUDY OF CHROMOSOMAL ABNORMALITIES AND HETEROMORPHISM IN COUPLES WITH 2 OR 3 RECURRENT ABORTIONS IN SHAHID BEHESHTI HOSPITAL OF HAMEDAN

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ASGARI ATEFEH; GHAHREMANI SAFIEH; SAEEDI SOLMAZ; KAMRANI EBRAHIM

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Journal Paper

Paper Information

Journal: International Journal of Reproductive BioMedicine Year:2013 | Volume:11 | Issue:3 Page(s): 201-208

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Title

THE STUDY OF CHROMOSOMAL ABNORMALITIES AND HETEROMORPHISM IN COUPLES WITH 2 OR 3 RECURRENT ABORTIONS IN SHAHID BEHESHTI HOSPITAL OF HAMEDAN

Author(s)

ASGARI ATEFEH | GHAHREMANI SAFIEH | SAEEDI SOLMAZ | KAMRANI EBRAHIM | Issue Writer Certificate

Keywords

TRANSLOCATION

HETEROMORPHISM

RECURRENT ABORTION

CHROMOSOMAL

ABNORMALITIES

Abstract

Background: Different studies show that CHROMOSOMAL balance TRANSLOCATION in the parents can cause recurrent spontaneous abortions. Incidence of CHROMOSOMAL TRANSLOCATION ABNORMALITIES in couples with repeated abortions is from 0% to 31%.Objective: The purpose of this research was studying the presence or absence of CHROMOSOMAL ABNORMALITIES and HETEROMORPHISM in couples with RECURRENT ABORTIONs and also the role of this anomaly in the abortions.Materials and Methods: This study is a cross sectional descriptive study which have investigated 75 couples who had three abortions or more, and 65 couples who had two abortions that referred by gynecologist to the lab of Beheshti Hospital in Hamedan for cytogenetical investigation. Also 40 healthy individuals without history of abortion investigated as control group.GTG bonding technique (staining banding with gymsa and trypsin) is used in this study.Results: Frequency of CHROMOSOMAL ABNORMALITIES and HETEROMORPHISM among couples with three or more abortions were reported respectively 5.3% and 9.3%. This frequency in couples with two abortions was respectively 3.07% and 6.15%. The frequency of CHROMOSOMAL HETEROMORPHISM in control group was 7.5% and no CHROMOSOMAL ABNORMALITIES were observed in them.Conclusion: This study shows that CHROMOSOMAL abnormality can be one reason of recurrent spontaneous abortions and more abortion increases the probability of this anomaly. Also, existence of CHROMOSOMAL HETEROMORPHISM in the general population without clinical abortion symptoms shows that CHROMOSOMAL HETEROMORPHISM cannot be the reason of these spontaneous abortions.

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APA: Copy

ASGARI, ATEFEH, GHAHREMANI, SAFIEH, SAEEDI, SOLMAZ, & KAMRANI, EBRAHIM. (2013). THE STUDY OF CHROMOSOMAL ABNORMALITIES AND HETEROMORPHISM IN COUPLES WITH 2 OR 3 RECURRENT ABORTIONS IN SHAHID BEHESHTI HOSPITAL OF HAMEDAN. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 11(3), 201-208. SID. https://sid.ir/paper/295961/en

Vancouver: Copy

ASGARI ATEFEH, GHAHREMANI SAFIEH, SAEEDI SOLMAZ, KAMRANI EBRAHIM. THE STUDY OF CHROMOSOMAL ABNORMALITIES AND HETEROMORPHISM IN COUPLES WITH 2 OR 3 RECURRENT ABORTIONS IN SHAHID BEHESHTI HOSPITAL OF HAMEDAN. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2013;11(3):201-208. Available from: https://sid.ir/paper/295961/en

IEEE: Copy

ATEFEH ASGARI, SAFIEH GHAHREMANI, SOLMAZ SAEEDI, and EBRAHIM KAMRANI, “THE STUDY OF CHROMOSOMAL ABNORMALITIES AND HETEROMORPHISM IN COUPLES WITH 2 OR 3 RECURRENT ABORTIONS IN SHAHID BEHESHTI HOSPITAL OF HAMEDAN,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 11, no. 3, pp. 201–208, 2013, [Online]. Available: https://sid.ir/paper/295961/en

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