مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

PROTECTIVE EFFECT OF ROYAL JELLY ON FERTILITY AND BIOCHEMICAL PARAMETERS IN BLEOMYCIN-INDUCED MALE RATS

Pages

  209-216

Abstract

 Background: BLEOMYCIN (BL) is a glycopeptide antibiotic obtained from the bacterium Streptomyces verticillus which is routinely used for treatment of human cancers. ROYAL JELLY (RJ) is a production from the hypo pharyngeal, mandibular and post cerebral glands of nurse bees. RJ consists of 66% water, 15% sugars, 5% lipids, and 13% proteins, essential amino acids and vitamins.Objective: The aim of present study was to evaluate protective effect of ROYAL JELLY on sperm parameters and malondialdehyde (MDA) production in RAT.Materials and Methods: Forty adult male wistar RATs (220±20gr) were randomly divided into 4 groups (n=10). Control group (CG) received normal saline 10 ml/kg twice a week with Intraperitoneal (I.P) for 48 days (0.3 ml/rat). ROYAL JELLY group (RJG) received jelly (100 mg/kg daily) for 48 days orally. BLEOMYCIN group (BLG) received BL (10 mg/kg twice a week) with I.P for 48 days. ROYAL JELLY+ BLEOMYCIN group (RJ+BLG) received ROYAL JELLY (100 mg/kg /day) orally concomitant with BL administration. Sperm count, motility, and viability were investigated and chromatin quality and DNA integrity were also analyzed. Serum TESTOSTERONE and MDA concentrations were measured as well.Results: BL caused decline significantly (p<0.05) sperm count, sperm viability, motility as well as TESTOSTERONE concentration compared to control group while significant (p<0.05) increases in immature sperm, sperm with damaged DNA and MDA concentration were announced in BL in comparison with CG and RJ+BLG. ROYAL JELLY improved BLEOMYCIN-induced toxicity on sperm parameters and TESTOSTERONE and MDA concentrations.Conclusion: The present results support the idea that BL adversely affects sperm parameters and MDA and the RJ with antioxidant properties has positive effects on these parameters.

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    APA: Copy

    AMIRSHAHI, TAYEBEH, NAJAFI, GHOLAMREZA, & NEJATI, VAHID. (2014). PROTECTIVE EFFECT OF ROYAL JELLY ON FERTILITY AND BIOCHEMICAL PARAMETERS IN BLEOMYCIN-INDUCED MALE RATS. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 12(3), 209-216. SID. https://sid.ir/paper/296084/en

    Vancouver: Copy

    AMIRSHAHI TAYEBEH, NAJAFI GHOLAMREZA, NEJATI VAHID. PROTECTIVE EFFECT OF ROYAL JELLY ON FERTILITY AND BIOCHEMICAL PARAMETERS IN BLEOMYCIN-INDUCED MALE RATS. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2014;12(3):209-216. Available from: https://sid.ir/paper/296084/en

    IEEE: Copy

    TAYEBEH AMIRSHAHI, GHOLAMREZA NAJAFI, and VAHID NEJATI, “PROTECTIVE EFFECT OF ROYAL JELLY ON FERTILITY AND BIOCHEMICAL PARAMETERS IN BLEOMYCIN-INDUCED MALE RATS,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 12, no. 3, pp. 209–216, 2014, [Online]. Available: https://sid.ir/paper/296084/en

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