ANTI-MULLERIAN AND ANDROGENS HORMONES IN WOMEN WITH POLYCYSTIC OVARY SYNDROME UNDERGOING IVF/ICSI

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SWELLAM MENHA; KHAIAL ABEER; MOSA TAMER EL SAIED; EL BAZ HATIM; SAID MOHAMED

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Journal: International Journal of Reproductive BioMedicine Year:2013 | Volume:11 | Issue:11 Page(s): 883-890

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Title

ANTI-MULLERIAN AND ANDROGENS HORMONES IN WOMEN WITH POLYCYSTIC OVARY SYNDROME UNDERGOING IVF/ICSI

Author(s)

Keywords

POLYCYSTIC OVARY SYNDROME

ANDROGEN HORMONE

ANTI-MULLERIAN HORMONE

ANDROSTENEDIONE

Abstract

Background: Despite its frequency, the POLYCYSTIC OVARY SYNDROME (PCOS) is still a difficult diagnosis in endocrinology, gynecology, and reproductive medicine. The Rotterdam consensus conference proposed to include the ultrasonographic follicle count as a new diagnostic criterion. Unfortunately, its assessment does not offer sufficient reliability worldwide.Objective: To explore the possible roles of altered circulating androgens and ANTI-MULLERIAN HORMONE among PCOS women regarding their body mass index and their outcomes after IVF.Materials and Methods: In this cross sectional study, 195 women with PCO were included, they were divided according to their body mass index (BMI <27 kg/m2) as obese PCOS (n=91) and overweight PCOS (BMI ≥27 kg/m2) (n=104). Serum levels of androgens (dehydroepiandrosterone sulfate [DHEAS], testosterone and ANDROSTENEDIONE [A4]), and ANTI-MULLERIAN HORMONE (AMH) were assessed and compared with the endocrine profile and cycles outcomes.Results: AMH, A4, FSH, and TSH concentrations were significantly higher in obese than in overweight women (p˂0.001). Contrary, LH: FSH ratio values, E2, PRL and DAHE-S levels were significantly lower in obese than in overweight women (p˂0.0001). Total oocyte retrieved, mature and fertilized oocyte were significantly higher in obese than in overweight women. Among pregnant obese PCOS women both AMH and A4 were significantly increased and DAHE-S was significantly decreased compared to pregnant overweight PCOS women.Conclusion: Obese PCOS women have a higher chance of getting pregnant over those categorized as overweight PCOS. Also, androgens and AMH levels recommended to be considered in IVF attributes among obese and overweight PCOS women.

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APA: Copy

SWELLAM, MENHA, KHAIAL, ABEER, MOSA, TAMER EL SAIED, EL BAZ, HATIM, & SAID, MOHAMED. (2013). ANTI-MULLERIAN AND ANDROGENS HORMONES IN WOMEN WITH POLYCYSTIC OVARY SYNDROME UNDERGOING IVF/ICSI. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 11(11), 883-890. SID. https://sid.ir/paper/296092/en

Vancouver: Copy

SWELLAM MENHA, KHAIAL ABEER, MOSA TAMER EL SAIED, EL BAZ HATIM, SAID MOHAMED. ANTI-MULLERIAN AND ANDROGENS HORMONES IN WOMEN WITH POLYCYSTIC OVARY SYNDROME UNDERGOING IVF/ICSI. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2013;11(11):883-890. Available from: https://sid.ir/paper/296092/en

IEEE: Copy

MENHA SWELLAM, ABEER KHAIAL, TAMER EL SAIED MOSA, HATIM EL BAZ, and MOHAMED SAID, “ANTI-MULLERIAN AND ANDROGENS HORMONES IN WOMEN WITH POLYCYSTIC OVARY SYNDROME UNDERGOING IVF/ICSI,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 11, no. 11, pp. 883–890, 2013, [Online]. Available: https://sid.ir/paper/296092/en

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