THE EXPRESSION OF TOLL-LIKE RECEPTORS (TLRS) IN TESTICULAR CANCER: A CASE CONTROL STUDY

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SHAPOURI FARNAZ; SAEIDI SHAGHAYEGH; ASHRAFI KAKHKI SARA; POUYAN OMID; AMIRCHAGHMAGHI ELHAM; AFLATOONIAN REZA

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Journal: International Journal of Reproductive BioMedicine Year:2013 | Volume:11 | Issue:11 Page(s): 919-924

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Title

THE EXPRESSION OF TOLL-LIKE RECEPTORS (TLRS) IN TESTICULAR CANCER: A CASE CONTROL STUDY

Author(s)

Keywords

TOLL- LIKE RECEPTORS (TLRS)

TESTICULAR CANCER

INNATE IMMUNITY

NF-KAPPA B

Abstract

Background: It has been suggested that malfunction of immune system may causes TESTICULAR CANCER. Recently, our understanding of innate immune system has been expanded, by discovery of “Toll-Like Receptors” (TLRs). Some studies have shown that polymorphisms of TLR2 and 4 may affect on the risk of cancer. Also, the role of TLRs 3 and 9 have been shown in apoptosis and metastasis of cancer cells in animal models.Objective: Little information is available about the influence of INNATE IMMUNITY on testicular malignancy. Therefore, expression of TLRs 2, 3, 4 and 9 as main components of INNATE IMMUNITY has been investigated in this study.Materials and Methods: In this case control study, TLRs gene expression was examined by RT-PCR in normal testis and TESTICULAR CANCER tissues. Real time quantitative PCR (Q-PCR) analysis was used to compare the relative expression of TLRs between the samples.Results: mRNAs of TLR 2, 3, 4 and 9 were expressed in all normal and cancer samples. Q-PCR reveals that cancer samples had stronger expression of these genes compared with normal ones.Conclusion: It seems that the different TLRs expression in TESTICULAR CANCER cells may contribute to extensive signaling pathways involved in carcinogenesis.

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APA: Copy

SHAPOURI, FARNAZ, SAEIDI, SHAGHAYEGH, ASHRAFI KAKHKI, SARA, POUYAN, OMID, AMIRCHAGHMAGHI, ELHAM, & AFLATOONIAN, REZA. (2013). THE EXPRESSION OF TOLL-LIKE RECEPTORS (TLRS) IN TESTICULAR CANCER: A CASE CONTROL STUDY. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 11(11), 919-924. SID. https://sid.ir/paper/296094/en

Vancouver: Copy

SHAPOURI FARNAZ, SAEIDI SHAGHAYEGH, ASHRAFI KAKHKI SARA, POUYAN OMID, AMIRCHAGHMAGHI ELHAM, AFLATOONIAN REZA. THE EXPRESSION OF TOLL-LIKE RECEPTORS (TLRS) IN TESTICULAR CANCER: A CASE CONTROL STUDY. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2013;11(11):919-924. Available from: https://sid.ir/paper/296094/en

IEEE: Copy

FARNAZ SHAPOURI, SHAGHAYEGH SAEIDI, SARA ASHRAFI KAKHKI, OMID POUYAN, ELHAM AMIRCHAGHMAGHI, and REZA AFLATOONIAN, “THE EXPRESSION OF TOLL-LIKE RECEPTORS (TLRS) IN TESTICULAR CANCER: A CASE CONTROL STUDY,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 11, no. 11, pp. 919–924, 2013, [Online]. Available: https://sid.ir/paper/296094/en

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