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Information Journal Paper

Title

IDENTIFICATION OF XQ22.1-23 AS A REGION LINKED WITH HEREDITARY RECURRENT SPONTANEOUS ABORTION IN A FAMILY

Pages

  659-664

Abstract

 Background: RECURRENT SPONTANEOUS ABORTION (RSA) is one of the most common health complications with a strong genetic component. Several genetic disorders were identified as etiological factors of hereditary X linked RSA. However, more genetic factors remain to be identified.Objective: In this study we performed LINKAGE analysis on a large X linked RSA pedigree to find a novel susceptibility locus for RSA.Materials and Methods: A LINKAGE scan using 11 microsatellites was performed in 27 members of a large pedigree of hereditary X-LINKED RSA. Two point parametric LINKAGE was performed using Superlink v 1.6 program.Results: Evidence of LINKAGE was observed to markers at Xq23, DXS7133 and at Xq22.1 DXS101, with LOD score of 3.12 and 1.60, respectively. Conclusion: Identified locus in this study may carry a responsible gene in RSA. Narrowing down of this region may leads to identification of this gene.

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    • Cite

    APA: Copy

    SHEKOUHI, SAHAR, BAGHBANI, FATEMEH, HASANZADEH NAZARABADI, MOHAMMAD, HAMZEHLOIE, TAYEBEH, ABBASZADEGAN, MOHAMMAD REZA, SAGHAFI, NAFISEH, RAOOFIAN, REZA, ZAVAR REZA, JAVAD, AHMAD ZADEH, SHAHAB, TABATABAIEFAR, MOHAMMAD AMIN, & MOJARRAD, MAJID. (2013). IDENTIFICATION OF XQ22.1-23 AS A REGION LINKED WITH HEREDITARY RECURRENT SPONTANEOUS ABORTION IN A FAMILY. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 11(8), 659-664. SID. https://sid.ir/paper/296111/en

    Vancouver: Copy

    SHEKOUHI SAHAR, BAGHBANI FATEMEH, HASANZADEH NAZARABADI MOHAMMAD, HAMZEHLOIE TAYEBEH, ABBASZADEGAN MOHAMMAD REZA, SAGHAFI NAFISEH, RAOOFIAN REZA, ZAVAR REZA JAVAD, AHMAD ZADEH SHAHAB, TABATABAIEFAR MOHAMMAD AMIN, MOJARRAD MAJID. IDENTIFICATION OF XQ22.1-23 AS A REGION LINKED WITH HEREDITARY RECURRENT SPONTANEOUS ABORTION IN A FAMILY. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2013;11(8):659-664. Available from: https://sid.ir/paper/296111/en

    IEEE: Copy

    SAHAR SHEKOUHI, FATEMEH BAGHBANI, MOHAMMAD HASANZADEH NAZARABADI, TAYEBEH HAMZEHLOIE, MOHAMMAD REZA ABBASZADEGAN, NAFISEH SAGHAFI, REZA RAOOFIAN, JAVAD ZAVAR REZA, SHAHAB AHMAD ZADEH, MOHAMMAD AMIN TABATABAIEFAR, and MAJID MOJARRAD, “IDENTIFICATION OF XQ22.1-23 AS A REGION LINKED WITH HEREDITARY RECURRENT SPONTANEOUS ABORTION IN A FAMILY,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 11, no. 8, pp. 659–664, 2013, [Online]. Available: https://sid.ir/paper/296111/en

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