METFORMIN VERSUS CHROMIUM PICOLINATE IN CLOMIPHENE CITRATE-RESISTANT PATIENTS WITH PCOS: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AMOOEE SEDIGHEH; PARSANEZHAD MOHAMMAD EBRAHIM; RAVANBOD SHIRAZI MARYAM; ALBORZI SAEED; SAMSAMI ALAMTAJ

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Reproductive BioMedicine Year:2013 | Volume:11 | Issue:8 Page(s): 611-618

Download Full-Text

View:

326

Download:

149

Cites:

Information Journal Paper

Title

METFORMIN VERSUS CHROMIUM PICOLINATE IN CLOMIPHENE CITRATE-RESISTANT PATIENTS WITH PCOS: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL

Author(s)

Keywords

CHROMIUM PICOLINATE

METFORMIN

POLYCYSTIC OVARY SYNDROME (PCOS)

CLOMIPHEN RESISTANT

Abstract

Background: CHROMIUM PICOLINATE could be effective in clomiphen citrate resistant PCOS patients.Objective: To compare the effects of CHROMIUM PICOLINATE vs. METFORMIN in clomiphen citrate resistant PCOS patients.Materials and Methods: The present randomized clinical trial was performed on 92 women with clomiphen citrate-resistant PCOS at the clinics which were affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. The subjects were randomly assigned to two groups receiving either CHROMIUM PICOLINATE (200mg daily) or METFORMIN (1500mg daily) for 3 months. Anthropometric and hormonal profile were measured and compared both before and after the treatment. Ovulation and pregnancy rate was measured in the two study groups, as well.Results: CHROMIUM PICOLINATE significantly decreased fasting blood sugar (FBS) after 3 months of treatment (p=0.042). In the same way, the serum levels of fasting insulin had significantly decreased leading to an increase in insulin sensitivity as measured by QUICKI index (p=0.014). In comparison to the patients who received CHROMIUM PICOLINATE, those who received METFORMIN had significantly lower levels of testosterone (p=0.001) and free testosterone (p=0.001) after 3 months of treatment. Nevertheless, no significant difference was found between the two study groups regarding ovulation (p=0.417) and pregnancy rates (p=0.500).Conclusion: CHROMIUM PICOLINATE decreased FBS and insulin levels and, thus, increased insulin sensitivity in clomiphene citrate-resistance PCOS women. These effects were comparable with METFORMIN; however, METFORMIN treatment was associated with decreased hyperandrogenism. Overall, CHROMIUM PICOLINATE was better tolerated compared to METFORMIN; nonetheless, the two study groups were not significantly different regarding ovulation and pregnancy rates.

Cites

No record.

References

No record.

Cite

APA: Copy

AMOOEE, SEDIGHEH, PARSANEZHAD, MOHAMMAD EBRAHIM, RAVANBOD SHIRAZI, MARYAM, ALBORZI, SAEED, & SAMSAMI, ALAMTAJ. (2013). METFORMIN VERSUS CHROMIUM PICOLINATE IN CLOMIPHENE CITRATE-RESISTANT PATIENTS WITH PCOS: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 11(8), 611-618. SID. https://sid.ir/paper/296112/en

Vancouver: Copy

AMOOEE SEDIGHEH, PARSANEZHAD MOHAMMAD EBRAHIM, RAVANBOD SHIRAZI MARYAM, ALBORZI SAEED, SAMSAMI ALAMTAJ. METFORMIN VERSUS CHROMIUM PICOLINATE IN CLOMIPHENE CITRATE-RESISTANT PATIENTS WITH PCOS: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2013;11(8):611-618. Available from: https://sid.ir/paper/296112/en

IEEE: Copy

SEDIGHEH AMOOEE, MOHAMMAD EBRAHIM PARSANEZHAD, MARYAM RAVANBOD SHIRAZI, SAEED ALBORZI, and ALAMTAJ SAMSAMI, “METFORMIN VERSUS CHROMIUM PICOLINATE IN CLOMIPHENE CITRATE-RESISTANT PATIENTS WITH PCOS: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 11, no. 8, pp. 611–618, 2013, [Online]. Available: https://sid.ir/paper/296112/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops