THE PREVALENCE OF Y CHROMOSOME MICRODELETIONS IN PAKISTANI INFERTILE MEN

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SIDDIQUI RUBINA TABASSUM; MUJTABA NOSHEEN; NAZ MAMOONA

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Journal Paper

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Journal: International Journal of Reproductive BioMedicine Year:2013 | Volume:11 | Issue:8 Page(s): 619-624

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Title

THE PREVALENCE OF Y CHROMOSOME MICRODELETIONS IN PAKISTANI INFERTILE MEN

Author(s)

SIDDIQUI RUBINA TABASSUM | MUJTABA NOSHEEN | NAZ MAMOONA | Issue Writer Certificate

Keywords

MALE INFERTILITY

AZOOSPERMIA

Y CHROMOSOME DELETIONS

Abstract

Background: Microdeletions of the AZOOSPERMIA factor locus of the long arm of Y chromosome are an etiological factor of severe oligozoospermia or AZOOSPERMIA. Objective: The aim of this study was to investigate the prevalence of Y-chromosome microdeletions in AZF region and their role in infertility in Pakistani population. Materials and Methods: The type of deletions in AZF locus were detected in infertile men (n=113) and the association of Y chromosome microdeletions with MALE INFERTILITY was assessed by including men (50) with normal karyotype and having children. Y chromosome microdeletions were detected by multiplex PCR using 10 sequence tagged sites namely sY81, sY130, sY141, sY142, sY155, sY157, sY160, sY182, sY231, and sY202 that covered all three regions of AZF. Results: Individuals with severe oligozoospermia showed 2.86% deletion frequency in AZFc region as compared to azoospermic males (5.5%). Conclusion: The results of our study showed that deletions in Y chromosome are not playing major part in MALE INFERTILITY. Moreover, multiplex-PCR strategy might preferably be employed for the detection of Y chromosome microdeletions allied to MALE INFERTILITY.

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APA: Copy

SIDDIQUI, RUBINA TABASSUM, MUJTABA, NOSHEEN, & NAZ, MAMOONA. (2013). THE PREVALENCE OF Y CHROMOSOME MICRODELETIONS IN PAKISTANI INFERTILE MEN. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 11(8), 619-624. SID. https://sid.ir/paper/296118/en

Vancouver: Copy

SIDDIQUI RUBINA TABASSUM, MUJTABA NOSHEEN, NAZ MAMOONA. THE PREVALENCE OF Y CHROMOSOME MICRODELETIONS IN PAKISTANI INFERTILE MEN. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2013;11(8):619-624. Available from: https://sid.ir/paper/296118/en

IEEE: Copy

RUBINA TABASSUM SIDDIQUI, NOSHEEN MUJTABA, and MAMOONA NAZ, “THE PREVALENCE OF Y CHROMOSOME MICRODELETIONS IN PAKISTANI INFERTILE MEN,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 11, no. 8, pp. 619–624, 2013, [Online]. Available: https://sid.ir/paper/296118/en

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