ULTRASTRUCTURAL AND MORPHOMETRICAL STUDY OF PREIMPLANTATION ENDOMETRIUM IN SUPEROVULATED MICE TREATED WITH PROGESTERONE OR SILDENAFIL

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ROSHANGAR LEILA; SOLEIMANI RAD JAFAR; RASHIDI BAHMAN; MAZOCHIAN HOSSEIN; NIKZAD BEHZAD; SOLEIMANI RAD SARA

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Journal: International Journal of Reproductive BioMedicine Year:2013 | Volume:11 | Issue:10 Page(s): 807-814

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Title

ULTRASTRUCTURAL AND MORPHOMETRICAL STUDY OF PREIMPLANTATION ENDOMETRIUM IN SUPEROVULATED MICE TREATED WITH PROGESTERONE OR SILDENAFIL

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Keywords

IMPLANTATION

PROGESTERONE

SILDENAFIL

MICE

UTERINE

Abstract

Background: Endometrial development has an important role in blastocyst adhesion and IMPLANTATION. During IVF cycles, endometrial development is enhanced by PROGESTERONE.Objective: The aim of this study was to compare ultrastructural and morphometrical characteristics of MICE UTERINE endometrium in natural cycle with those in superovulated cycles received PROGESTERONE or SILDENAFIL.Materials and Methods: In This study, 60 female bulb/c MICE were divided into 4 groups: a control and 3 experimental; gonadotropin, gonadotropin+ SILDENAFIL and gonadotropin+ PROGESTERONE. In experimental groups the MICE superovulated mated. In the gonadotropin+ PROGESTERONE and gonadotropin+ Viagra groups, the MICE respectively received 1mg PROGESTERONE and 3 mg SILDENAFIL citrate. Their UTERINE specimens were prepared for morphometrical and ultrastructural study. Height of the epithelial cells was measured, using motic software. Statistical analysis was performed using ANOVA.Results: Microscopy revealed that in control group the cells had numerous apical microvilli and the height of the cells was 20.52±2.43 mm. In gonadotropin+ PROGESTERONE group, the granules were found in basal and apical portions and cellular height were 17.91±2.78 mm which were significantly shorter than in the control and gonadotropin groups (p<0.001). In this group, the apical membrane also contained pinopodes. In gonadotropin +Sildenafil group, the granules were found in both apical and basal portions and the height of the cells were 17.60±2.49 mm which were significantly shorter than in the control and gonadotropin groups (p<0.001). In this group, pinopodes appeared slightly extensive than the other groups.Conclusion: It is concluded that superovulatory drugs in MICE stimulate endometrial maturation but injection of SILDENAFIL is nearly more positive.

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APA: Copy

ROSHANGAR, LEILA, SOLEIMANI RAD, JAFAR, RASHIDI, BAHMAN, MAZOCHIAN, HOSSEIN, NIKZAD, BEHZAD, & SOLEIMANI RAD, SARA. (2013). ULTRASTRUCTURAL AND MORPHOMETRICAL STUDY OF PREIMPLANTATION ENDOMETRIUM IN SUPEROVULATED MICE TREATED WITH PROGESTERONE OR SILDENAFIL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 11(10), 807-814. SID. https://sid.ir/paper/296128/en

Vancouver: Copy

ROSHANGAR LEILA, SOLEIMANI RAD JAFAR, RASHIDI BAHMAN, MAZOCHIAN HOSSEIN, NIKZAD BEHZAD, SOLEIMANI RAD SARA. ULTRASTRUCTURAL AND MORPHOMETRICAL STUDY OF PREIMPLANTATION ENDOMETRIUM IN SUPEROVULATED MICE TREATED WITH PROGESTERONE OR SILDENAFIL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2013;11(10):807-814. Available from: https://sid.ir/paper/296128/en

IEEE: Copy

LEILA ROSHANGAR, JAFAR SOLEIMANI RAD, BAHMAN RASHIDI, HOSSEIN MAZOCHIAN, BEHZAD NIKZAD, and SARA SOLEIMANI RAD, “ULTRASTRUCTURAL AND MORPHOMETRICAL STUDY OF PREIMPLANTATION ENDOMETRIUM IN SUPEROVULATED MICE TREATED WITH PROGESTERONE OR SILDENAFIL,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 11, no. 10, pp. 807–814, 2013, [Online]. Available: https://sid.ir/paper/296128/en

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