NEW SINGLE NUCLEOTIDE POLYMORPHISM G5508A IN THE SEPT12 GENE MAY BE ASSOCIATED WITH IDIOPATHIC MALE INFERTILITY IN IRANIAN MEN

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SHAHHOSEINI MARYAM; AZAD MAHNAZ; SABBAGHIAN MARJAN; SHAFIPOUR MARYAM; AKHOOND MOHAMMAD REZA; SALMAN YAZDI REZA; SADIGHI GILANI MOHAMMAD ALI; GOURABI HAMID

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Journal: International Journal of Reproductive BioMedicine Year:2015 | Volume:13 | Issue:8 Page(s): 503-506

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Title

NEW SINGLE NUCLEOTIDE POLYMORPHISM G5508A IN THE SEPT12 GENE MAY BE ASSOCIATED WITH IDIOPATHIC MALE INFERTILITY IN IRANIAN MEN

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Keywords

MALE INFERTILITY

POLYMORPHISM

SEPT12

SEPTIN

SPERMATOGENESIS

Abstract

Background: MALE INFERTILITY is a multifactorial disorder, which affects approximately 10% of couples at childbearing age with substantial clinical and social impact. Genetic factors are associated with the susceptibility to spermatogenic impairment in humans. Recently, SEPT12 is reported as a critical gene for SPERMATOGENESIS. This gene encodes a testis specific member of SEPTIN proteins, a family of polymerizing GTP-binding proteins. SEPT12 in association with other SEPTINs is an essential annulus component in mature sperm. So, it is hypothesized that genetic alterations of SEPT12 may be concerned in MALE INFERTILITY.Objective: The objective of this research is exploration of new single nucleotide POLYMORPHISM G5508A in the SEPT12 gene association with idiopathic MALE INFERTILITY in Iranian men.Materials and Methods: In this case control study, 67 infertile men and 100 normal controls were analyzed for genetic alterations in the active site coding region of SEPT12, using polymerase chain reaction sequencing technique. Fisher exact test was used for statistical analysis and p<0.05 was considered as statistically significant.Results: Genotype analysis indicated that G5508A polymorphic SEPT12 alleles were distributed in three peaks of frequency in both control and diseases groups. Categorization of the alleles into (GG), (GA), (AA) types revealed a significant difference between infertile patients (azoospermic and asthenospermic) and normal controls (p=0.005).Conclusion: According to our finding we suggest that G5508A POLYMORPHISM in SEPT12 gene can affect SPERMATOGENESIS in men, the opinion needs more investigation in different populations.

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APA: Copy

SHAHHOSEINI, MARYAM, AZAD, MAHNAZ, SABBAGHIAN, MARJAN, SHAFIPOUR, MARYAM, AKHOOND, MOHAMMAD REZA, SALMAN YAZDI, REZA, SADIGHI GILANI, MOHAMMAD ALI, & GOURABI, HAMID. (2015). NEW SINGLE NUCLEOTIDE POLYMORPHISM G5508A IN THE SEPT12 GENE MAY BE ASSOCIATED WITH IDIOPATHIC MALE INFERTILITY IN IRANIAN MEN. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 13(8), 503-506. SID. https://sid.ir/paper/296199/en

Vancouver: Copy

SHAHHOSEINI MARYAM, AZAD MAHNAZ, SABBAGHIAN MARJAN, SHAFIPOUR MARYAM, AKHOOND MOHAMMAD REZA, SALMAN YAZDI REZA, SADIGHI GILANI MOHAMMAD ALI, GOURABI HAMID. NEW SINGLE NUCLEOTIDE POLYMORPHISM G5508A IN THE SEPT12 GENE MAY BE ASSOCIATED WITH IDIOPATHIC MALE INFERTILITY IN IRANIAN MEN. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2015;13(8):503-506. Available from: https://sid.ir/paper/296199/en

IEEE: Copy

MARYAM SHAHHOSEINI, MAHNAZ AZAD, MARJAN SABBAGHIAN, MARYAM SHAFIPOUR, MOHAMMAD REZA AKHOOND, REZA SALMAN YAZDI, MOHAMMAD ALI SADIGHI GILANI, and HAMID GOURABI, “NEW SINGLE NUCLEOTIDE POLYMORPHISM G5508A IN THE SEPT12 GENE MAY BE ASSOCIATED WITH IDIOPATHIC MALE INFERTILITY IN IRANIAN MEN,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 13, no. 8, pp. 503–506, 2015, [Online]. Available: https://sid.ir/paper/296199/en

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