THE EFFECTS OF VITAMIN D SUPPLEMENTATION ON MATERNAL AND NEONATAL OUTCOME: A RANDOMIZED CLINICAL TRIAL

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MOJIBIAN MAHDIEH; SOHEILYKHAH SEDIGHEH; FALLAH ZADEH MOHAMMAD ALI; JANNATI MOGHADAM MARYAM

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Journal: International Journal of Reproductive BioMedicine Year:2015 | Volume:13 | Issue:11 Page(s): 687-696

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Title

THE EFFECTS OF VITAMIN D SUPPLEMENTATION ON MATERNAL AND NEONATAL OUTCOME: A RANDOMIZED CLINICAL TRIAL

Author(s)

MOJIBIAN MAHDIEH | SOHEILYKHAH SEDIGHEH | FALLAH ZADEH MOHAMMAD ALI | JANNATI MOGHADAM MARYAM | Issue Writer Certificate

Keywords

VITAMIN D

PREGNANCY OUTCOME

GESTATIONAL DIABETES

Abstract

Background: VITAMIN D supplementation during pregnancy has been supposed to defend against adverse gestational outcomes.Objective: This randomized clinical trial study was conducted to assess the effects of 50, 000 IU of VITAMIN D every two weeks supplementation on the incidence of GESTATIONAL DIABETES (GDM), gestational hypertension, preeclampsia and preterm labor, VITAMIN D status at term and neonatal outcomes contrasted with pregnant women that received 400 IU VITAMIN D daily.Materials and Methods: 500 women with gestational age 12-16 weeks and serum 25 hydroxy VITAMIN D (25 (OH) D) less than 30 ng/ml randomly categorized in two groups. Group A received 400 IU VITAMIN D daily and group B 50, 000 IU VITAMIN D every 2 weeks orally until delivery. Maternal and Neonatal outcomes were assessed in two groups.Results: The incidence of GDM in group B was significantly lower than group A (6.7% versus 13.4%) and odds ratio (95% Confidence interval) was 0.46 (0.24-0.87) (P=0.01). The mean ± SD level of 25 (OH) D at the time of delivery in mothers in group B was significantly higher than A (37.9 ± 19.8 versus 27.2 ± 18.8 ng/ml, respectively) (P=0.001). There were no differences in the incidence of preeclampsia, gestational hypertension, preterm labor, and low birth weight between two groups. The mean level of 25 (OH) D in cord blood of group B was significantly higher than group A (37.9±18 versus 29.7 ± 19ng/ml, respectively). Anthropometric measures between neonates were not significantly different.Conclusion: Our study showed 50, 000 IU VITAMIN D every 2 weeks decreased the incidence of GDM.

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APA: Copy

MOJIBIAN, MAHDIEH, SOHEILYKHAH, SEDIGHEH, FALLAH ZADEH, MOHAMMAD ALI, & JANNATI MOGHADAM, MARYAM. (2015). THE EFFECTS OF VITAMIN D SUPPLEMENTATION ON MATERNAL AND NEONATAL OUTCOME: A RANDOMIZED CLINICAL TRIAL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 13(11), 687-696. SID. https://sid.ir/paper/296229/en

Vancouver: Copy

MOJIBIAN MAHDIEH, SOHEILYKHAH SEDIGHEH, FALLAH ZADEH MOHAMMAD ALI, JANNATI MOGHADAM MARYAM. THE EFFECTS OF VITAMIN D SUPPLEMENTATION ON MATERNAL AND NEONATAL OUTCOME: A RANDOMIZED CLINICAL TRIAL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2015;13(11):687-696. Available from: https://sid.ir/paper/296229/en

IEEE: Copy

MAHDIEH MOJIBIAN, SEDIGHEH SOHEILYKHAH, MOHAMMAD ALI FALLAH ZADEH, and MARYAM JANNATI MOGHADAM, “THE EFFECTS OF VITAMIN D SUPPLEMENTATION ON MATERNAL AND NEONATAL OUTCOME: A RANDOMIZED CLINICAL TRIAL,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 13, no. 11, pp. 687–696, 2015, [Online]. Available: https://sid.ir/paper/296229/en

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