EFFECT OF BODY WEIGHT ON SERUM HOMOCYSTEINE LEVEL IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME: A CASE CONTROL STUDY

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AL GAREEB ALI I.; SALAH ABD AL AMIEER WAFAA; ALKURAISHY HAYDER M.; AL MAYAHI THABAT J.

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Journal: International Journal of Reproductive BioMedicine Year:2016 | Volume:14 | Issue:2 Page(s): 81-88

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Title

EFFECT OF BODY WEIGHT ON SERUM HOMOCYSTEINE LEVEL IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME: A CASE CONTROL STUDY

Author(s)

AL GAREEB ALI I. | SALAH ABD AL AMIEER WAFAA | ALKURAISHY HAYDER M. | AL MAYAHI THABAT J. | Issue Writer Certificate

Keywords

HOMOCYSTEINE

BODY WEIGHT

POLYCYSTIC OVARIAN SYNDROME

Abstract

Background: POLYCYSTIC OVARIAN SYNDROME (PCOS) represent one of the common endocrine disorders which influence around 8% of reproductive women whom usually suffering from obesity and increase cardiovascular risk. Serum HOMOCYSTEINE levels are associated with bad impact on endothelial functions and considered as an independent risk factor for cardiovascular disease.Objective: The aim was to study the level of plasma HOMOCYSTEINE in obese and non-obese Iraqi patients with PCOS.Materials and Methods: This study was carried out on 207 women. Of theme, 101 women with PCOS and 106 PCOS- free women served as controls. Blood sample was taken from each participant on the 2nd day of menstruation morning after an overnight fasting. Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), free testosterone and androstenedione were measured. Moreover, total lipid profile and plasma HOMOCYSTEINE levels were measured in both groups.Results: Sixty percent of PCOS women were overweight or obese and 56% of them had a waist circumference>88cm. Moreover plasma HOMOCYSTEINE concentrations were found to be higher in patients with PCOS (11.5±5.41mmol/L) as compared with control (8.10±1.89 mmol/L) (p<0.002). Furthermore the HOMOCYSTEINE concentrations were 13.19±5.97 mmol/L and 9.38±2.99 mmol/L in both obese and normal-weight PCOS women respectively which was significantly higher than obese (p<0.002) and normal-weight (p<0.004) control women.Conclusion: Increase in BODY WEIGHT is not an independent risk factor to increase plasma HOMOCYSTEINE levels in PCOS women.

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APA: Copy

AL GAREEB, ALI I., SALAH ABD AL AMIEER, WAFAA, ALKURAISHY, HAYDER M., & AL MAYAHI, THABAT J.. (2016). EFFECT OF BODY WEIGHT ON SERUM HOMOCYSTEINE LEVEL IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME: A CASE CONTROL STUDY. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 14(2), 81-88. SID. https://sid.ir/paper/296247/en

Vancouver: Copy

AL GAREEB ALI I., SALAH ABD AL AMIEER WAFAA, ALKURAISHY HAYDER M., AL MAYAHI THABAT J.. EFFECT OF BODY WEIGHT ON SERUM HOMOCYSTEINE LEVEL IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME: A CASE CONTROL STUDY. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2016;14(2):81-88. Available from: https://sid.ir/paper/296247/en

IEEE: Copy

ALI I. AL GAREEB, WAFAA SALAH ABD AL AMIEER, HAYDER M. ALKURAISHY, and THABAT J. AL MAYAHI, “EFFECT OF BODY WEIGHT ON SERUM HOMOCYSTEINE LEVEL IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME: A CASE CONTROL STUDY,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 14, no. 2, pp. 81–88, 2016, [Online]. Available: https://sid.ir/paper/296247/en

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