ASSOCIATION STUDY OF GLUTATHIONE S-TRANSFERASE POLYMORPHISMS AND RISK OF ENDOMETRIOSIS IN AN IRANIAN POPULATION

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HASSANI MINA; SALIMINEJAD KIOOMARS; HEIDARIZADEH MASOOD; KAMALI KOOROSH; MEMARIANI TOKTAM; KHORRAM KHORSHID HAMID REZA

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Journal: International Journal of Reproductive BioMedicine Year:2016 | Volume:14 | Issue:4 Page(s): 241-246

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Title

ASSOCIATION STUDY OF GLUTATHIONE S-TRANSFERASE POLYMORPHISMS AND RISK OF ENDOMETRIOSIS IN AN IRANIAN POPULATION

Author(s)

Keywords

ENDOMETRIOSIS

ASSOCIATION STUDY

GSTM1

GSTT1

GSTP1

POLYMORPHISM

Abstract

Background: ENDOMETRIOSIS influenced by both genetic and environmental factors. Associations of glutathione S-transferases (GSTs) genes POLYMORPHISMs in ENDOMETRIOSIS have been investigated by various researchers; however, the results are not consistent.Objective: We examined the associations of GSTM1 and GSTT1 null genotypes and GSTP1 313 A/G POLYMORPHISMs with ENDOMETRIOSIS in an Iranian population.Materials and Methods: In this case-control study, 151 women with diagnosis of ENDOMETRIOSIS and 156 normal healthy women as control group were included. The genotyping was determined using multiplex PCR and PCR- RFLP methods.Results: The GSTM1 null genotype was significantly higher (p=0.027) in the cases (7.3%) than the control group (1.3%). There was no significant difference between the frequency of GSTT1 genotypes between the cases and controls. The GSTP1 313 AG genotype was significantly lower (p=0.048) in the case (33.1%) than the control group (44.4%).Conclusion: Our results showed that GSTM1 and GSTP1 POLYMORPHISMs may be associated with susceptibility of ENDOMETRIOSIS in Iranian women.

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APA: Copy

HASSANI, MINA, SALIMINEJAD, KIOOMARS, HEIDARIZADEH, MASOOD, KAMALI, KOOROSH, MEMARIANI, TOKTAM, & KHORRAM KHORSHID, HAMID REZA. (2016). ASSOCIATION STUDY OF GLUTATHIONE S-TRANSFERASE POLYMORPHISMS AND RISK OF ENDOMETRIOSIS IN AN IRANIAN POPULATION. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 14(4), 241-246. SID. https://sid.ir/paper/296261/en

Vancouver: Copy

HASSANI MINA, SALIMINEJAD KIOOMARS, HEIDARIZADEH MASOOD, KAMALI KOOROSH, MEMARIANI TOKTAM, KHORRAM KHORSHID HAMID REZA. ASSOCIATION STUDY OF GLUTATHIONE S-TRANSFERASE POLYMORPHISMS AND RISK OF ENDOMETRIOSIS IN AN IRANIAN POPULATION. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2016;14(4):241-246. Available from: https://sid.ir/paper/296261/en

IEEE: Copy

MINA HASSANI, KIOOMARS SALIMINEJAD, MASOOD HEIDARIZADEH, KOOROSH KAMALI, TOKTAM MEMARIANI, and HAMID REZA KHORRAM KHORSHID, “ASSOCIATION STUDY OF GLUTATHIONE S-TRANSFERASE POLYMORPHISMS AND RISK OF ENDOMETRIOSIS IN AN IRANIAN POPULATION,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 14, no. 4, pp. 241–246, 2016, [Online]. Available: https://sid.ir/paper/296261/en

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