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Information Journal Paper

Title

THE EFFECT OF STEM CELL FACTOR ON PROLIFERATION OF HUMAN ENDOMETRIAL CD146+ CELLS

Pages

  437-442

Abstract

 Background: STEM CELL FACTOR (SCF) is a transcriptional factor which plays crucial roles in normal proliferation, differentiation and survival in a range of stem cells.Objective: The aim of the present study was to examine the proliferation effect of different concentrations of SCF on expansion of human endometrial CD146+ cells.Materials and Methods: In this experimental study, total populations of isolated human endometrial suspensions after fourth passage were isolated by magnetic activated cell sorting (MACS) into CD146+ cells. Human endometrial CD146+ cells were karyotyped and tested for the effect of SCF on proliferation of CD146+ cells, then different concentrations of 0, 12.5, 25, 50 and 100 ng/ml was carried out and mitogens-stimulated endometrial CD146+ cells proliferation was assessed by MTT assay.Results: Chromosomal analysis showed a normal metaphase spread and 46XX karyotype. The proliferation rate of endometrial CD146P+ P cells in the presence of 0, 12.5, 25, 50 and 100 ng/ml SCF were 0.945±0.094, 0.962±0.151, 0.988±0.028, 1.679±0.012 and 1.129±0.145 respectively. There was a significant increase in stem/ stromal cell proliferation following in vitro treatment by 50 ng/ml than other concentrations of SCF (p=0.01).Conclusion: The present study suggests that SCF could have effect on the proliferation and cell survival of human endometrial CD146P+P cells and it has important implications for medical sciences and cell therapies.

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    APA: Copy

    FAYAZI, MEHRI, SALEHNIA, MOJDEH, & ZIAEI, SAEIDEH. (2016). THE EFFECT OF STEM CELL FACTOR ON PROLIFERATION OF HUMAN ENDOMETRIAL CD146+ CELLS. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 14(7), 437-442. SID. https://sid.ir/paper/296297/en

    Vancouver: Copy

    FAYAZI MEHRI, SALEHNIA MOJDEH, ZIAEI SAEIDEH. THE EFFECT OF STEM CELL FACTOR ON PROLIFERATION OF HUMAN ENDOMETRIAL CD146+ CELLS. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2016;14(7):437-442. Available from: https://sid.ir/paper/296297/en

    IEEE: Copy

    MEHRI FAYAZI, MOJDEH SALEHNIA, and SAEIDEH ZIAEI, “THE EFFECT OF STEM CELL FACTOR ON PROLIFERATION OF HUMAN ENDOMETRIAL CD146+ CELLS,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 14, no. 7, pp. 437–442, 2016, [Online]. Available: https://sid.ir/paper/296297/en

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