ENDOGENOUS LUTEINIZING HORMONE CONCENTRATION AND IVF OUTCOME DURING OVARIAN STIMULATION IN FIXED VERSUS FLEXIBLE GNRH ANTAGONIST PROTOCOLS: AN RCT

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DEPALO RAFFAELLA; TREROTOLI PAOLO; CHINCOLI ANNAROSA; PATRIZIA VACCA MARGHERITA; LAMANNA GIUSEPPINA; CICINELLI ETTORE

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Journal: International Journal of Reproductive BioMedicine Year:2018 | Volume:16 | Issue:3 Page(s): 175-182

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Title

ENDOGENOUS LUTEINIZING HORMONE CONCENTRATION AND IVF OUTCOME DURING OVARIAN STIMULATION IN FIXED VERSUS FLEXIBLE GNRH ANTAGONIST PROTOCOLS: AN RCT

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Keywords

IN VITRO FERTILIZATION

LUTEINIZING HORMONE

OVARIAN STIMULATION

OUTCOME

Abstract

Background: LUTEINIZING HORMONE (LH) is essential for normal follicular development and oocyte maturation. In particular, fluctuations of LH during the follicular phase have a significant impact on morphological and functional changes of the oocyte and determine its meiotic status and ability to be fertilized.Objective: This prospective randomized controlled trial examined effects of endogenous follicular phase LH levels on oocyte maturity and IVF OUTCOMEs in fixed vs. flexible IN VITRO FERTILIZATION.Materials and Methods: Normo-ovulatory women age<39 yr (n=213) were randomized to fixed or flexible gonadotrophin-releasing hormone (GnRH) antagonist protocols. Follicular phase LH, estradiol, and progesterone profiles were measured. Oocytes retrieved, implantation rate, and pregnancy rate were compared between the two groups.Results: LH profiles were similar in both protocols. A lower trend of LH values at the end of OVARIAN STIMULATION correlated significantly with a higher pregnancy rate, regardless of protocol (p=0.02). Estradiol levels were statistically different with respect to time points within treatment groups (p<0.0001), but not between groups (p=0.43), or pregnancy OUTCOMEs (p=0.2595). Progesterone profiles were similar between groups. No differences were found in retrieved oocytes numbers, fertilization rate or embryos obtained. Significantly, younger age and a higher number of antral follicles were correlated with positive results.Conclusion: Fixed and flexible GnRH antagonist protocols did not produce an oscillation of endogenous LH values correlated to the OUTCOME of OVARIAN STIMULATION.

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APA: Copy

DEPALO, RAFFAELLA, TREROTOLI, PAOLO, CHINCOLI, ANNAROSA, PATRIZIA VACCA, MARGHERITA, LAMANNA, GIUSEPPINA, & CICINELLI, ETTORE. (2018). ENDOGENOUS LUTEINIZING HORMONE CONCENTRATION AND IVF OUTCOME DURING OVARIAN STIMULATION IN FIXED VERSUS FLEXIBLE GNRH ANTAGONIST PROTOCOLS: AN RCT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 16(3), 175-182. SID. https://sid.ir/paper/296344/en

Vancouver: Copy

DEPALO RAFFAELLA, TREROTOLI PAOLO, CHINCOLI ANNAROSA, PATRIZIA VACCA MARGHERITA, LAMANNA GIUSEPPINA, CICINELLI ETTORE. ENDOGENOUS LUTEINIZING HORMONE CONCENTRATION AND IVF OUTCOME DURING OVARIAN STIMULATION IN FIXED VERSUS FLEXIBLE GNRH ANTAGONIST PROTOCOLS: AN RCT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2018;16(3):175-182. Available from: https://sid.ir/paper/296344/en

IEEE: Copy

RAFFAELLA DEPALO, PAOLO TREROTOLI, ANNAROSA CHINCOLI, MARGHERITA PATRIZIA VACCA, GIUSEPPINA LAMANNA, and ETTORE CICINELLI, “ENDOGENOUS LUTEINIZING HORMONE CONCENTRATION AND IVF OUTCOME DURING OVARIAN STIMULATION IN FIXED VERSUS FLEXIBLE GNRH ANTAGONIST PROTOCOLS: AN RCT,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 16, no. 3, pp. 175–182, 2018, [Online]. Available: https://sid.ir/paper/296344/en

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