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Information Journal Paper

Title

THE NON-PREVENTIVE EFFECTS OF HUMAN MENOPAUSAL GONADOTROPINS ON OVARIAN TISSUES IN NANDROLONE DECANOATE-TREATED FEMALE RATS: A HISTOCHEMICAL AND ULTRA-STRUCTURAL STUDY

Pages

  159-174

Abstract

 Background: The follicular growth and development may be affected by abused drugs. NANDROLONE DECANOATE (ND) as an anabolic androgenic steroid can damage the morphological and functional features of the ovary and may lead to reproductive failure.Objective: This study was designed to evaluate the effects of synchronized and nonsynchronized administration of Human Menopausal Gonadotropins (hMG) with ND on ovarian tissue and level of sex hormones in the adult female RAT.Materials and Methods: Forty adult female Sprague Dawley RATs were divided into eight groups. The five experimental groups received 3 and/or 10 mg/kg of ND synchronized and non-synchronized with 10 IU of HMG and HMG alone. The two shams and control groups received solvents of ND and HMG. The animals' serum levels of Follicle-stimulating hormone, Luteinizing hormone, progesterone and estrogen and the weight, volume and dimensions of the ovaries were measured. The ovaries were prepared for APOPTOSIS assessment and morphological study.Results: The ovarian volume and sex hormones in the experimental groups were decreased, but ovarian weight anddimensions didn’t change. The RATe of APOPTOSIS was increased in the experimental groups as follows; a low and high dose of ND synchronized with HMG 48.80±18.70 and 65.20±14.20 respectively vs. Sham 1, 33.20±17.80, a low and high dose of ND non-synchronized with hMD 55.80±17.20 and 75.20±14.30 respectively vs. Sham 2, 31.60±32.40groups, p˂0.01. Follicular and stromal cells were damaged in the experimental groups except for the HMG group.Conclusion: Administration of ND decreased the serum level of Luteinizing hormone, Follicle-stimulating hormone, progesterone and estrogen and damaged ovarian tissue irreversibly and irreparably and HMG cannot prevent the destruction of the follicles in the adult female RATs. This can be a serious warning to women who abuse ND.

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    Cite

    APA: Copy

    MESBAH, FAKHRODDIN, BORDBAR, HOSSEIN, TALAEI KHOZANI, TAHEREH, DEHGHANI, FARZANEH, & MIRKHANI, HOSSEIN. (2018). THE NON-PREVENTIVE EFFECTS OF HUMAN MENOPAUSAL GONADOTROPINS ON OVARIAN TISSUES IN NANDROLONE DECANOATE-TREATED FEMALE RATS: A HISTOCHEMICAL AND ULTRA-STRUCTURAL STUDY. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 16(3), 159-174. SID. https://sid.ir/paper/296346/en

    Vancouver: Copy

    MESBAH FAKHRODDIN, BORDBAR HOSSEIN, TALAEI KHOZANI TAHEREH, DEHGHANI FARZANEH, MIRKHANI HOSSEIN. THE NON-PREVENTIVE EFFECTS OF HUMAN MENOPAUSAL GONADOTROPINS ON OVARIAN TISSUES IN NANDROLONE DECANOATE-TREATED FEMALE RATS: A HISTOCHEMICAL AND ULTRA-STRUCTURAL STUDY. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2018;16(3):159-174. Available from: https://sid.ir/paper/296346/en

    IEEE: Copy

    FAKHRODDIN MESBAH, HOSSEIN BORDBAR, TAHEREH TALAEI KHOZANI, FARZANEH DEHGHANI, and HOSSEIN MIRKHANI, “THE NON-PREVENTIVE EFFECTS OF HUMAN MENOPAUSAL GONADOTROPINS ON OVARIAN TISSUES IN NANDROLONE DECANOATE-TREATED FEMALE RATS: A HISTOCHEMICAL AND ULTRA-STRUCTURAL STUDY,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 16, no. 3, pp. 159–174, 2018, [Online]. Available: https://sid.ir/paper/296346/en

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