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Information Journal Paper

Title

Antioxidant effect of genistein on ovarian tissue morphology, oxidant and antioxidant activity in rats with induced polycystic ovary syndrome

Pages

  11-22

Abstract

 Background: Oxidative stress is the most frequent cause of female infertility disorders including Polycystic Ovary syndrome (PCOS). Genistein as a major component of soybean isoflavone scavenges free radicals by Antioxidant activities. Objective: The present study examines the Antioxidant effects of Genistein on ovarian tissue following experimental PCOS in Rats. Materials and Methods: Twenty female Wistar rat were randomly divided into the following groups (n=5 each group): (I) control group (no treatment); (II) induced PCOS (injection of estradiol valerate); (III) Genistein-treated non-PCOS (received Genistein); and (IV) Genistein-treated PCOS groups. The weight of Rats were measured and the blood samples collected and centrifuged. The oxidant and Antioxidant activity of plasma and ovaries were measured. All Rats were sacrificed under anesthesia, and ovaries were collected and weighted. Histological examination and follicular quality were assessed by staining. Results: In histological observation, the induced PCOS Rats displayed more number of atretic Follicles and the follicular quality in Genistein-treated Rats was similar to the control groups. The plasma and ovaries malondialdehyde levels significantly increased in PCOS Rats (p < 0. 001), while the total Antioxidant capacity levels, glutathione peroxidase, and superoxide dismutase activities significantly decreased (p < 0. 001). The plasma and Ovary malondialdehyde levels significantly decreased in PCOS Rats that were treated with Genistein (p < 0. 001) and the total Antioxidant capacity (p < 0. 05), glutathione peroxidase, and superoxide dismutase activities significantly increased (p < 0. 001). Conclusion: Treatment with Genistein preserved follicular quality by increasing Antioxidant activities and scavenging oxidant levels in PCOS Rats.

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    APA: Copy

    RAJAEI, SAMIRA, ALIHEMMATI, ALIREZA, & ABEDELAHI, ALI. (2019). Antioxidant effect of genistein on ovarian tissue morphology, oxidant and antioxidant activity in rats with induced polycystic ovary syndrome. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 17(1), 11-22. SID. https://sid.ir/paper/296368/en

    Vancouver: Copy

    RAJAEI SAMIRA, ALIHEMMATI ALIREZA, ABEDELAHI ALI. Antioxidant effect of genistein on ovarian tissue morphology, oxidant and antioxidant activity in rats with induced polycystic ovary syndrome. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2019;17(1):11-22. Available from: https://sid.ir/paper/296368/en

    IEEE: Copy

    SAMIRA RAJAEI, ALIREZA ALIHEMMATI, and ALI ABEDELAHI, “Antioxidant effect of genistein on ovarian tissue morphology, oxidant and antioxidant activity in rats with induced polycystic ovary syndrome,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 17, no. 1, pp. 11–22, 2019, [Online]. Available: https://sid.ir/paper/296368/en

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