Increased expression of stemness genes REX-1, OCT4, NANOG, and SOX-2 in women with ovarian endometriosis versus normal endometrium: A case-control study

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SHARIATI FATEMEH; FAVAEDI RAHA; Ramazanali Fariba; GHORAEIAN PEGAH; AFSHARIAN PARVANEH; AFLATOONIAN BEHROUZ; AFLATOONIAN REZA; SHAHHOSEINI MARYAM

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Journal: International Journal of Reproductive BioMedicine Year:2018 | Volume:16 | Issue:12 Page(s): 783-790

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Title

Increased expression of stemness genes REX-1, OCT4, NANOG, and SOX-2 in women with ovarian endometriosis versus normal endometrium: A case-control study

Author(s)

Keywords

Endometriosis

Stemness genes

Abstract

Background: Endometriosis is a common, chronic inflammatory disease which is defined as an overgrowth of endometrial tissue outside the uterine cavity. The etiology of this disease is complex and multifactorial but there is a strong evidence that supports the presence of endometrial stem cells and their possible involvement in Endometriosis. Objective: In this study, we analyzed the mRNA expression of REX-1 stemness gene and reconsidered three other Stemness genes SOX-2, NANOG, OCT-4 in women with Endometriosis compared to normal endometrium. Materials and Methods: Ten ectopic and ten eutopic tissue samples along with 23 normal endometrium specimens were recruited in this study. The expression levels of OCT-4, NANOG, SOX-2, and REX-1 genes were evaluated by the quantitative real-time polymerase chain reaction. Results: The transcription levels of OCT-4, NANOG, and SOX-2 mRNA were significantly increased in ectopic lesions compared with eutopic and control group (p = 0. 041, p = 0. 035, p = 0. 048), although the REX-1 mRNA increase was not significant between Endometriosis and control groups. Also, there were differences in the expression level of these genes in normal endometrium during the menstrual cycles (p = 0. 031, p = 0. 047, p = 0. 031). Conclusion: Based on our data, we confirm the dynamic role of Stemness genes in proliferation and growth of normal endometrium during the menstrual cycle and conclude that differential expression.

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APA: Copy

FAVAEDI, RAHA, Ramazanali, Fariba, GHORAEIAN, PEGAH, AFSHARIAN, PARVANEH, AFLATOONIAN, BEHROUZ, AFLATOONIAN, REZA, & SHAHHOSEINI, MARYAM. (2018). Increased expression of stemness genes REX-1, OCT4, NANOG, and SOX-2 in women with ovarian endometriosis versus normal endometrium: A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 16(12), 783-790. SID. https://sid.ir/paper/296383/en

Vancouver: Copy

FAVAEDI RAHA, Ramazanali Fariba, GHORAEIAN PEGAH, AFSHARIAN PARVANEH, AFLATOONIAN BEHROUZ, AFLATOONIAN REZA, SHAHHOSEINI MARYAM. Increased expression of stemness genes REX-1, OCT4, NANOG, and SOX-2 in women with ovarian endometriosis versus normal endometrium: A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2018;16(12):783-790. Available from: https://sid.ir/paper/296383/en

IEEE: Copy

RAHA FAVAEDI, Fariba Ramazanali, PEGAH GHORAEIAN, PARVANEH AFSHARIAN, BEHROUZ AFLATOONIAN, REZA AFLATOONIAN, and MARYAM SHAHHOSEINI, “Increased expression of stemness genes REX-1, OCT4, NANOG, and SOX-2 in women with ovarian endometriosis versus normal endometrium: A case-control study,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 16, no. 12, pp. 783–790, 2018, [Online]. Available: https://sid.ir/paper/296383/en

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