Frequency of TNFR1 36 A/G gene polymorphism in azoospermic infertile men: A case-control study

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ASHRAFZADEH HAMID REZA; NAZARI TAHEREH; DEHGHAN TEZERJANI MASOUD; KHADEMI BAMI MARYAM; GHASEMI ESMAILABAD SAEED; GHASEMI NASRIN

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Journal: International Journal of Reproductive BioMedicine Year:2017 | Volume:15 | Issue:8 Page(s): 521-526

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Title

Frequency of TNFR1 36 A/G gene polymorphism in azoospermic infertile men: A case-control study

Author(s)

Keywords

Polymorphism

Male infertility

Spermatozoa

Cytokines

Tumor necrosis factor alpha.

Abstract

Background: Tumor necrosis factor-alpha (TNF-α ) is a multifunctional cytokine that regulates different cellular activities related to spermatogenesis. Tumor necrosis factor-alpha receptor 1 (TNFR1) mediates TNF-α activity and Polymorphism in TNFR1 could lead to gene dysfunction and Male infertility. Objective: The aim of this study is to determine the association of TNFR1 36 A/G Polymorphism with the idiopathic azoospermia in Iranian population. Materials and Methods: This case-control study included 108 azoospermic and 119 fertile men. This research investigated the frequency of TNFR1 36 A/G Polymorphism in cases who were idiopathic azoospermic men referred to Yazd Research and Clinical Center for Infertility, Iran in comparison with controls. polymerase chain reaction-restriction fragment length Polymorphism (PCR-RFLP) method was used to investigate the Polymorphism in both case and control groups. PCR fragments were digested by Mspa1I enzyme and products were appeared by gel electrophoresis. The abundance of A→ G was calculated in the azoospermic and healthy men. Results: According to the present study, GG and AG genotypes frequency in the azoospermic men group were higher than the control group (OR= 2. 298 (1. 248-4. 229), p=0. 007), (OR=1. 47 (0. 869-2. 498, p=0. 149). Our findings also showed that G allele frequency in azoospermic men had significant difference compared to the control group (OR=2. 302 (1. 580-3. 355), p<0. 001). Conclusion: It seems that the GG genotype and G allele have an association with increased risk of non-obstructive azoospermia.

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APA: Copy

ASHRAFZADEH, HAMID REZA, NAZARI, TAHEREH, DEHGHAN TEZERJANI, MASOUD, KHADEMI BAMI, MARYAM, GHASEMI ESMAILABAD, SAEED, & GHASEMI, NASRIN. (2017). Frequency of TNFR1 36 A/G gene polymorphism in azoospermic infertile men: A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 15(8), 521-526. SID. https://sid.ir/paper/296391/en

Vancouver: Copy

ASHRAFZADEH HAMID REZA, NAZARI TAHEREH, DEHGHAN TEZERJANI MASOUD, KHADEMI BAMI MARYAM, GHASEMI ESMAILABAD SAEED, GHASEMI NASRIN. Frequency of TNFR1 36 A/G gene polymorphism in azoospermic infertile men: A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2017;15(8):521-526. Available from: https://sid.ir/paper/296391/en

IEEE: Copy

HAMID REZA ASHRAFZADEH, TAHEREH NAZARI, MASOUD DEHGHAN TEZERJANI, MARYAM KHADEMI BAMI, SAEED GHASEMI ESMAILABAD, and NASRIN GHASEMI, “Frequency of TNFR1 36 A/G gene polymorphism in azoospermic infertile men: A case-control study,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 15, no. 8, pp. 521–526, 2017, [Online]. Available: https://sid.ir/paper/296391/en

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