Protective effect of green tea extract on the deltamethrin-induced toxicity in mice testis: An experimental study

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Bagherpour Hoda; KARIMPOUR MALEKSHAH ABBASALI; TALEBPOUR AMIRI FERESHTEH; AZADBAKHT MOHAMMAD

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Journal: International Journal of Reproductive BioMedicine Year:2019 | Volume:17 | Issue:5 Page(s): 337-348

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Title

Protective effect of green tea extract on the deltamethrin-induced toxicity in mice testis: An experimental study

Author(s)

Bagherpour Hoda | KARIMPOUR MALEKSHAH ABBASALI | TALEBPOUR AMIRI FERESHTEH | AZADBAKHT MOHAMMAD | Issue Writer Certificate

Keywords

Deltamethrin

Green tea

Oxidative stress

Testis

Caspase-3

Abstract

Background: Deltamethrin (DM) is one of the environmental factors that can have destructive effects on the male fertility. Green tea (GT) as a medicinal herb, has antioxidant property. Objective: The present study investigated the protective role of GT extract in improving the harmful effects of DM on the Testis. Materials and Methods: In this experimental study, 35 adult male mice (25– 30 gr) were divided in to five groups (n = 7/each). The control group received only normal saline. Sham received 0. 2 ml corn oil. Green tea group received only GT of 150 mg/kg. bw; Deltamethrin group received the DM at a dose of 0. 6 mg/kg. bw; GT + DM received both GT and DM. The effect of GT was assessed by measuring Oxidative stress markers, sperm parameters, histological and immunohistochemical analysis. Results: The results showed that the count and motility of spermatozoa, testosterone, and Malondialdehyde significantly decreased (p < 0. 001) and the abnormal spermatozoa increased (p < 0. 001) in DM group compared to control group. Moreover, enhanced Caspase-3expression and apoptosis were observed in DM-treated mice compared to control group. Histologically, DM with a degenerative effect on testicular tissue reduced the spermatogenesis progenitor cells. The epithelial height and the diameter of the seminiferous tubules were also reduced in the DM group. Treatment with GT in the DM-treated mice significantly improved these changes. Conclusion: With these findings, it was concluded that the GT treatment with antioxidant activity and anti-apoptotic property could protect the testicular injury induced by DM.

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APA: Copy

Bagherpour, Hoda, KARIMPOUR MALEKSHAH, ABBASALI, TALEBPOUR AMIRI, FERESHTEH, & AZADBAKHT, MOHAMMAD. (2019). Protective effect of green tea extract on the deltamethrin-induced toxicity in mice testis: An experimental study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 17(5), 337-348. SID. https://sid.ir/paper/296449/en

Vancouver: Copy

Bagherpour Hoda, KARIMPOUR MALEKSHAH ABBASALI, TALEBPOUR AMIRI FERESHTEH, AZADBAKHT MOHAMMAD. Protective effect of green tea extract on the deltamethrin-induced toxicity in mice testis: An experimental study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2019;17(5):337-348. Available from: https://sid.ir/paper/296449/en

IEEE: Copy

Hoda Bagherpour, ABBASALI KARIMPOUR MALEKSHAH, FERESHTEH TALEBPOUR AMIRI, and MOHAMMAD AZADBAKHT, “Protective effect of green tea extract on the deltamethrin-induced toxicity in mice testis: An experimental study,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 17, no. 5, pp. 337–348, 2019, [Online]. Available: https://sid.ir/paper/296449/en

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