The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trial

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MESDAGHINIA ELAHEH; Mohammad Ebrahimi Behnaz; FOROOZANFARD FATEMEH; BANAFSHE HAMID REZA

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Journal Paper

Paper Information

Journal: International Journal of Reproductive BioMedicine Year:2017 | Volume:15 | Issue:10 Page(s): 635-640

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Title

The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trial

Author(s)

MESDAGHINIA ELAHEH | Mohammad Ebrahimi Behnaz | FOROOZANFARD FATEMEH | BANAFSHE HAMID REZA | Issue Writer Certificate

Keywords

Recurrent abortion

Aspirin

Vitamin E

Pulsatility index

Abstract

Background: Recurrent spontaneous abortion has high incidence rate. The etiology is unknown in 30-40%. However high uterine artery resistance is accounted as one of the Recurrent abortion reasons. Objective: The objective of the current study was to determine the impacts of Vitamin E and Aspirin on the uterine artery blood flow in women having Recurrent abortions due to impaired uterine blood flow. Materials and Methods: This randomized clinical trial was conducted on 99 women having uterine Pulsatility index (PI) more than 2. 5 and the history of more than two times abortions. The candidates were categorized into three groups; receiving Aspirin, only Vitamin E, and Aspirin+Vitamin E. After 2 months, uterine PIs were compared with each other. Results: All drug regimens caused an enhancement in uterine perfusion with a significant decline in uterine artery PI value. The women receiving Vitamin E in accompanied with Aspirin had the least mean PI of the uterine artery (p<0. 001). The total average PI score of the right and left uterine arteries in groups receiving Vitamin E in accompanied with Aspirin was lower than the two counterparts significantly (p<0. 001). Conclusion: Vitamin E, Aspirin and especially their combination are effective in improving uterine artery blood flow in women with Recurrent abortion due to impaired uterine blood flow. More well-designed studies are needed to find out whether the enhancement of uterine perfusion may lead to a better pregnancy outcome.

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APA: Copy

MESDAGHINIA, ELAHEH, Mohammad Ebrahimi, Behnaz, FOROOZANFARD, FATEMEH, & BANAFSHE, HAMID REZA. (2017). The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trial. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 15(10), 635-640. SID. https://sid.ir/paper/296481/en

Vancouver: Copy

MESDAGHINIA ELAHEH, Mohammad Ebrahimi Behnaz, FOROOZANFARD FATEMEH, BANAFSHE HAMID REZA. The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trial. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2017;15(10):635-640. Available from: https://sid.ir/paper/296481/en

IEEE: Copy

ELAHEH MESDAGHINIA, Behnaz Mohammad Ebrahimi, FATEMEH FOROOZANFARD, and HAMID REZA BANAFSHE, “The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trial,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 15, no. 10, pp. 635–640, 2017, [Online]. Available: https://sid.ir/paper/296481/en

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