Administration of high dose of methamphetamine has detrimental effects on sperm parameters and DNA integrity in mice

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Sabour Mojdeh; KHORADMEHR AREZOO; KALANTAR SEYYED MEHDI; Danafar Amir Hossein; OMIDI MARJAN; HALVAEI IMAN; NABI ALI; GHASEMI ESMAILABAD SAEED; TALEBI ALI REZA

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Journal: International Journal of Reproductive BioMedicine Year:2017 | Volume:15 | Issue:3 Page(s): 161-168

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Title

Administration of high dose of methamphetamine has detrimental effects on sperm parameters and DNA integrity in mice

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Keywords

Methamphetamine

Apoptosis

Sperm

Sperm chromatin

Abstract

Background: Methamphetamine (MA) was shown to have harmful effects on male reproductive system. Objective: To investigate probable effects of daily administration of MA on Sperm parameters and chromatin/DNA integrity in mouse. Material and Methods: Thirty-five NMRI male mice were divided into five groups including low, medium, and high dosage groups which were injected intraperitoneally with 4, 8 and 15 mg/kg/day for 35 days, respectively. Normal saline was injected in sham group and no medications were used in control group. Then, the mice were killed and caudal epididymis of each animal was cut and placed in Ham’ s F10 medium for Sperm retrieval. To evaluate Sperm chromatin abnormalities, the aniline blue, toluidine blue and chromomycine A3 were used. For Sperm DNA integrity and Apoptosis, the acridine orange, Sperm chromatin dispersion, and TUNEL assay were applied. For Sperm morphology, Papanicolaou staining was done Results: Normal morphology and progressive motility of Spermatozoa decreased in medium and high dosage groups in comparison with the control group (p=0. 035). There was a significant increase in rate of aniline blue, toluidine blue, and chromomycine A3 positive Spermatozoa in high dosage group. In a similar manner, there was an increase in rates of acridine orange, TUNEL and Sperm chromatin dispersion positive Sperm cells in high dosage group with respect to others. Conclusion: MA abuse in a dose-dependent manner could have detrimental effects on male reproductive indices including Sperm parameters and Sperm chromatin/DNA integrity in mice.

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APA: Copy

Sabour, Mojdeh, KHORADMEHR, AREZOO, Danafar, Amir Hossein, OMIDI, MARJAN, HALVAEI, IMAN, NABI, ALI, GHASEMI ESMAILABAD, SAEED, & TALEBI, ALI REZA. (2017). Administration of high dose of methamphetamine has detrimental effects on sperm parameters and DNA integrity in mice. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 15(3), 161-168. SID. https://sid.ir/paper/296526/en

Vancouver: Copy

Sabour Mojdeh, KHORADMEHR AREZOO, Danafar Amir Hossein, OMIDI MARJAN, HALVAEI IMAN, NABI ALI, GHASEMI ESMAILABAD SAEED, TALEBI ALI REZA. Administration of high dose of methamphetamine has detrimental effects on sperm parameters and DNA integrity in mice. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2017;15(3):161-168. Available from: https://sid.ir/paper/296526/en

IEEE: Copy

Mojdeh Sabour, AREZOO KHORADMEHR, Amir Hossein Danafar, MARJAN OMIDI, IMAN HALVAEI, ALI NABI, SAEED GHASEMI ESMAILABAD, and ALI REZA TALEBI, “Administration of high dose of methamphetamine has detrimental effects on sperm parameters and DNA integrity in mice,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 15, no. 3, pp. 161–168, 2017, [Online]. Available: https://sid.ir/paper/296526/en

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