Protective effects of melatonin on testis histology following acute torsion-detorsion in rats

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MIRHOSEINI MEHRI; TALEBPOUR AMIRI FERESHTEH; KARIMPOUR MALEKSHAH ABBAS ALI; Rezanejad Gatabi Zahra; GHAFFARI ELMIRA

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Journal: International Journal of Reproductive BioMedicine Year:2017 | Volume:15 | Issue:3 Page(s): 141-146

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Title

Protective effects of melatonin on testis histology following acute torsion-detorsion in rats

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Keywords

Spermatic cord torsion

Testis

Melatonin

MDA

Rats

Abstract

Background: Testicular damage due to Spermatic cord torsion may lead to infertility. It is probably because of changes in oxidative stress factors such as malondialdehyde. Objective: To investigate the protective effect of Melatonin (MLT), as an antioxidant, on testicular damage induced by acute unilateral Spermatic cord torsion and detorsion (T/D) in Rats. Materials and Methods: In this experimental study, 48 adult male Wistar Rats were randomly divided into three groups (8 Rats/group): sham group underwent right scrotal surgery only., the T/D group underwent right testicular torsion (for 1 hr) and detorsion, and the Melatonin group underwent right testicular torsion, received 25 μ g/kg Melatonin intraperitoneally immediately after surgery of T/D. Then the histological parameters and malondialdehyde (MDA) changes were evaluated. Results: Torsion and detorsion decreased the diameter of the tubules significantly compared to controls (p=0. 003). Melatonin could increase the diameter, but it was not significant (p=0. 26). The heights of the epithelium were constant in sham, T/D, and Melatonin groups without any significant difference between groups (p=0. 98). Based on Johnsen’ s score, spermatogenesis was normal in the sham group. The torsion significantly injured all lineage cells (p<0. 001). There was no any spermatid or sperm in the seminiferous tubules. Melatonin improved the spermatogenesis significantly (p=0. 02), but could not improve MDA level significantly (p=0. 99). Conclusion: Severe degenerative changes of Testis were induced by acute unilateral Spermatic cord torsion and detorsion in Rats, but it had no effect on MDA level.

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APA: Copy

MIRHOSEINI, MEHRI, TALEBPOUR AMIRI, FERESHTEH, KARIMPOUR MALEKSHAH, ABBAS ALI, Rezanejad Gatabi, Zahra, & GHAFFARI, ELMIRA. (2017). Protective effects of melatonin on testis histology following acute torsion-detorsion in rats. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 15(3), 141-146. SID. https://sid.ir/paper/296527/en

Vancouver: Copy

MIRHOSEINI MEHRI, TALEBPOUR AMIRI FERESHTEH, KARIMPOUR MALEKSHAH ABBAS ALI, Rezanejad Gatabi Zahra, GHAFFARI ELMIRA. Protective effects of melatonin on testis histology following acute torsion-detorsion in rats. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2017;15(3):141-146. Available from: https://sid.ir/paper/296527/en

IEEE: Copy

MEHRI MIRHOSEINI, FERESHTEH TALEBPOUR AMIRI, ABBAS ALI KARIMPOUR MALEKSHAH, Zahra Rezanejad Gatabi, and ELMIRA GHAFFARI, “Protective effects of melatonin on testis histology following acute torsion-detorsion in rats,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 15, no. 3, pp. 141–146, 2017, [Online]. Available: https://sid.ir/paper/296527/en

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