Ovary stereological features and serum biochemical factors following induction of polycystic ovary syndrome with testosterone enanthate in mice: An experimental study

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Kalhori Zahra; SOLEIMANI MEHRANJANI MALEK; AZADBAKHT MEHRI; Shariaatzadeh mohammad ali

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Journal: International Journal of Reproductive BioMedicine Year:2018 | Volume:16 | Issue:4 Page(s): 267-274

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Title

Ovary stereological features and serum biochemical factors following induction of polycystic ovary syndrome with testosterone enanthate in mice: An experimental study

Author(s)

Kalhori Zahra | SOLEIMANI MEHRANJANI MALEK | AZADBAKHT MEHRI | Shariaatzadeh mohammad ali | Issue Writer Certificate

Keywords

Polycystic ovary syndrome

Inflammation

Oxidative stress

Mice

Abstract

Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder featured by insulin resistance and hyperandrogenism. Testosterone enanthate can induce PCOS in Mice models. Objective: We investigated the ovary stereological features along with the Oxidative stress and inflammatory factors in Mice following PCOS induction using testosterone enanthate. Materials and Methods: Twelve female NMRI Mice (3 wk old) were divided into 2 groups (n=6/each): Control and PCOS. PCOS was induced through daily injections of testosterone enanthate (1 mg/100g subcutaneous s. c for 5 wk). Finally, ovaries were studied stereologically. The serum levels of the follicle-stimulating hormone, luteinizing hormone, testosterone, interleukin-6, and tumor necrosis factor-α were measured using ELISA kit. Serum levels of Malondialdehyde and the antioxidant capacity were measured relatively using thiobarbituric acid and ferric reducing antioxidant power assay. Results: The mean total volume of ovary and the mean volume of cortex (p<0. 001), volume of oocyte in the preantral (p=0. 011) and antral follicle (p=0. 015), thickness of zona pellucida (p=0. 016), the number of antral follicles (p=0. 012), the serum levels of follicle-stimulating hormone (p<0. 001) and the antioxidant capacity (p=0. 020) reduced significantly in the PCOS group compared to the control. The number of primary (p=0. 017) and preantral (p=0. 006) follicles and the serum levels of testosterone (p<0. 001), Luteinizing hormone (p=0. 002), Malondialdehyde, Interleukin 6 and Tumor necrosis factor-α (p<0. 001) showed a significant increase in the PCOS group compared to the control. Conclusion: Testosterone enanthate induced PCOS causes stereological features in the ovary, increases the Oxidative stress and inflammatory markers in Mice.

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References

ULTRA-STRUCTURAL STUDY BY TRANSMISSION ELECTRON MICROSCOPY: EFFECT OF OMEGA-3 ON OVARY CELL ORGANELLES AFTER EXPERIMENTAL INDUCED POLY CYSTIC OVARY SYNDROME

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APA: Copy

Kalhori, Zahra, SOLEIMANI MEHRANJANI, MALEK, AZADBAKHT, MEHRI, & Shariaatzadeh, mohammad ali. (2018). Ovary stereological features and serum biochemical factors following induction of polycystic ovary syndrome with testosterone enanthate in mice: An experimental study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 16(4), 267-274. SID. https://sid.ir/paper/296552/en

Vancouver: Copy

Kalhori Zahra, SOLEIMANI MEHRANJANI MALEK, AZADBAKHT MEHRI, Shariaatzadeh mohammad ali. Ovary stereological features and serum biochemical factors following induction of polycystic ovary syndrome with testosterone enanthate in mice: An experimental study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2018;16(4):267-274. Available from: https://sid.ir/paper/296552/en

IEEE: Copy

Zahra Kalhori, MALEK SOLEIMANI MEHRANJANI, MEHRI AZADBAKHT, and mohammad ali Shariaatzadeh, “Ovary stereological features and serum biochemical factors following induction of polycystic ovary syndrome with testosterone enanthate in mice: An experimental study,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 16, no. 4, pp. 267–274, 2018, [Online]. Available: https://sid.ir/paper/296552/en

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