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Information Journal Paper

Title

Diabetes mellitus increased integrins gene expression in rat endometrium at the time of embryo implantation

Pages

  395-404

Abstract

 Background: Diabetes mellitus deeply changes the genes expression of integrin (Itg) subunits in several cells and tissues such as monocytes, arterial endothelium, kidney glomerular cells, retina. Furthermore, hyperglycemia could impress and reduce the rate of successful assisted as well as non-assisted pregnancy. Endometrium undergoes thorough changes in normal menstrual cycle and the question is: What happens in the Endometrium under diabetic condition? Objective: The aim of the current study was to investigate the endometrial gene expression of α 3, α 4, α v, Itg β 1 and β 3 subunits in diabetic rat models at the time of Embryo implantation. Materials and Methods: Twenty-eight rats were randomly divided into 4 groups: control group, diabetic group, pioglitazone-treated group, and metformin-treated group. Realtime PCR was performed to determine changes in the expression of Itg α 3, α 4, α v, β 1, and β 3 genes in rat’ s Endometrium. Results: The expression of all Itg subunits increased significantly in diabetic rats’ Endometrium compared with control group. Treatment with pioglitazone significantly reduced the level of Itg subunits gene expression compared with diabetic rats. While metformin had a different effect on α 3 and α 4 and elevated these two subunits gene expression. Conclusion: Diabetes mellitus significantly increased the expression of studied Itg subunits, therefore untreated diabetes could be potentially assumed as one of the preliminary elements in Embryo implantation failure.

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    APA: Copy

    Bakhteyari, Abbas, ZARRIN, YASAMAN, HOSSEINY, ZEINAB SADAT, MOSTAFAVI, FATEMAH SADAT, ESKANDARI, NAHID, MATINFAR, MOHAMMAD, & ABOUTORABI, ROSHANAK. (2019). Diabetes mellitus increased integrins gene expression in rat endometrium at the time of embryo implantation. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 17(6), 395-404. SID. https://sid.ir/paper/296574/en

    Vancouver: Copy

    Bakhteyari Abbas, ZARRIN YASAMAN, HOSSEINY ZEINAB SADAT, MOSTAFAVI FATEMAH SADAT, ESKANDARI NAHID, MATINFAR MOHAMMAD, ABOUTORABI ROSHANAK. Diabetes mellitus increased integrins gene expression in rat endometrium at the time of embryo implantation. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2019;17(6):395-404. Available from: https://sid.ir/paper/296574/en

    IEEE: Copy

    Abbas Bakhteyari, YASAMAN ZARRIN, ZEINAB SADAT HOSSEINY, FATEMAH SADAT MOSTAFAVI, NAHID ESKANDARI, MOHAMMAD MATINFAR, and ROSHANAK ABOUTORABI, “Diabetes mellitus increased integrins gene expression in rat endometrium at the time of embryo implantation,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 17, no. 6, pp. 395–404, 2019, [Online]. Available: https://sid.ir/paper/296574/en

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