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Information Journal Paper

Title

The effects of myricitrin and vitamin E against reproductive changes induced by D-galactose as an aging model in female mice: An experimental study

Pages

  789-798

Abstract

 Background: Aging is accompanied by decreasing general function in the cells and tissues. D-galactose (D-gal) induces Aging and plays a role in the pathogenesis of it. Myricitrin is a plant-derived antioxidant. Objective: The present study was performed to evaluate the effects of Myricitrin on antioxidant defense, sex hormone levels, uterus, and ovarian histology in D-galinduced Aging female mouse model. Materials and Methods: In this experimental study, 72 female adult NMRI Mice, weighing 30-35 gr, 3-4 months old, were randomly divided into six groups (n = 12/each): (I) Control (vehicle; normal saline), (II) D-gal at 500 mg/kg/d for 45 days, (III-V) D-gal + Myricitrin-treated groups (these groups received Myricitrin at 5, 10, and 20 mg/kg/d, and (VI) D-gal + 100 mg/kg/d Vitamin E orally for the last 28 days. The antioxidant indices were done on the basis of colorimetric method, and sex hormone levels were measured by using enzyme-linked immunosorbent assay kits. Histological assessment of the uterus and ovaries were also evaluated. Results: D-gal impaired the estrous cycle, also degenerative changes occur in the ovarian follicles and damage to the uterus and ovarian tissue occurs. In D-gal group, the level of sex hormones (p = 0. 03) and the total antioxidant capacity (p = 0. 002) decreased, while the level of malondialdehyde and gonadotropins increased (p = 0. 03). Myricitrin at lower doses and Vitamin E ameliorated the D-gal effects. Conclusion: These findings suggest that Myricitrin at low doses can effectively prevent D-gal-induced oxidation and Aging in Mice. The effect of Myricitrin was equivalent and sometimes better than Vitamin E.

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    APA: Copy

    Omidi, Mina, AHANGARPOUR, AKRAM, MARD, SEYED ALI, & KHORSANDI, LAYASADAT. (2019). The effects of myricitrin and vitamin E against reproductive changes induced by D-galactose as an aging model in female mice: An experimental study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 17(11), 789-798. SID. https://sid.ir/paper/296613/en

    Vancouver: Copy

    Omidi Mina, AHANGARPOUR AKRAM, MARD SEYED ALI, KHORSANDI LAYASADAT. The effects of myricitrin and vitamin E against reproductive changes induced by D-galactose as an aging model in female mice: An experimental study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2019;17(11):789-798. Available from: https://sid.ir/paper/296613/en

    IEEE: Copy

    Mina Omidi, AKRAM AHANGARPOUR, SEYED ALI MARD, and LAYASADAT KHORSANDI, “The effects of myricitrin and vitamin E against reproductive changes induced by D-galactose as an aging model in female mice: An experimental study,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 17, no. 11, pp. 789–798, 2019, [Online]. Available: https://sid.ir/paper/296613/en

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