ANGIOTENSIN CONVERTING ENZYME GENE POLYMORPHISM IN IRANIAN PATIENTS WITH TYPE 2 DIABETES

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NIKZAMIR A.R.; GOLMOHAMMADI T.; ZAHRAEI M.; NAKHJAVANI M.; AMIRZARGAR ALI AKBAR

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Journal Paper

Paper Information

Journal: Iranian Journal of Immunology Year:2006 | Volume:3 | Issue:1 Page(s): 23-29

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Title

ANGIOTENSIN CONVERTING ENZYME GENE POLYMORPHISM IN IRANIAN PATIENTS WITH TYPE 2 DIABETES

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Keywords

ANGIOTENSIN CONVERTING ENZYME

TYPE 2 DIABETES

NEPHROPATHY

Abstract

Background: Genotype DD and D allele of Angiotensin I Converting Enzyme (ACE) may be involved with an increased susceptibility to TYPE 2 DIABETES and diabetic NEPHROPATHY (DN). Objective: To investigate the relationship between ACE I/D polymorphism and TYPE 2 DIABETES in 261 Iranian case-control pairs. Methods: 170 patients (85 type 2 diabetics with NEPHROPATHY and 85 type 2 diabetics without NEPHROPATHY) and 91 healthy control subjects formed the studied groups. I/D polymorphism of the ACE gene were detected by polymerase chain reaction (PCR) utilizing specific primers. Results: The frequency of DD genotype in the DN group was higher than that of the type 2 diabetic patients (30.6% vs. 20%, P-value=0.157) and the control group (30.6% vs. 14.3%, P-value=0.006).The frequency of D allele in nephropathic patients was 58.2% as compared to type 2 diabetic patients without NEPHROPATHY 50.5% (P-value=0.19) and control subjects 37.3% (P-value=0.001). The frequency of D allele in type 2 diabetic groups was found to be higher than that in the control group (p<0.01). Conclusion: Data of this investigation concluded that the D allele of ACE gene is more frequent in TYPE 2 DIABETES (DM) but frequency of DD genotype and D allele in type 2 diabetic patients with NEPHROPATHY and the control subjects were insignificant.

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APA: Copy

NIKZAMIR, A.R., GOLMOHAMMADI, T., ZAHRAEI, M., NAKHJAVANI, M., & AMIRZARGAR, ALI AKBAR. (2006). ANGIOTENSIN CONVERTING ENZYME GENE POLYMORPHISM IN IRANIAN PATIENTS WITH TYPE 2 DIABETES. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 3(1), 23-29. SID. https://sid.ir/paper/296737/en

Vancouver: Copy

NIKZAMIR A.R., GOLMOHAMMADI T., ZAHRAEI M., NAKHJAVANI M., AMIRZARGAR ALI AKBAR. ANGIOTENSIN CONVERTING ENZYME GENE POLYMORPHISM IN IRANIAN PATIENTS WITH TYPE 2 DIABETES. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2006;3(1):23-29. Available from: https://sid.ir/paper/296737/en

IEEE: Copy

A.R. NIKZAMIR, T. GOLMOHAMMADI, M. ZAHRAEI, M. NAKHJAVANI, and ALI AKBAR AMIRZARGAR, “ANGIOTENSIN CONVERTING ENZYME GENE POLYMORPHISM IN IRANIAN PATIENTS WITH TYPE 2 DIABETES,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 3, no. 1, pp. 23–29, 2006, [Online]. Available: https://sid.ir/paper/296737/en

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