مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

DETERMINATION OF HEPATITIS B SURFACE ANTIBODY TITER IN VACCINATED CHILDREN WITH MAJOR THALASSEMIA IN KERMAN-IRAN

Pages

  30-34

Abstract

 Background: THALASSEMIA patients, comparing to normal population are more susceptible to hepatitis, because of frequent blood transfusions. Objective: To determine the immune response of children with major ک-thalassemia, by measuring antihepatitis B surface antibody (anti-HBs Ab) following the last HBV vaccine injection. Method: This study carried out on 215 thalassemic children who received three standard intramuscular recombinant HBV vaccines. Children age range was between 1- 4.5 with a mean age of 3.37 years. Based on the time lapsed since last vaccine injection, the subjects were divided into three groups; 0-15 months, 15-30 months and 30- 45 months, respectively. Based on the serum levels of anti-HBs antibody, subjects were categorized as: good responders (anti-HBs >100 IU/Lit), low responders (anti- HBs 10-100 IU/Lit) and non responders (anti-HBs <10 IU/Lit). Results: The mean range of anti-HBs level in the above mentioned groups were 205.34, 128.8 and 54.25 IU/lit, respectively (P<0.0001). In girls, the mean antibody level was 104.2 and in boys it was 95.8 IU/Lit (P>0.05). Out of 215 selected individuals 75 (35%) were good responders, 65(30%) low responders and 75 (35%) non-responders. Conclusion: Standard HBV vaccination in thalassemic children results in an immune response in more than 65% of the subjects. Therefore, assessment of anti-HBs antibody level, 45 months after the last vaccination is recommended.

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    APA: Copy

    VAHIDI, A.A., VARES VAZIRIAN, M., & SHAMS ALDINI, A.. (2006). DETERMINATION OF HEPATITIS B SURFACE ANTIBODY TITER IN VACCINATED CHILDREN WITH MAJOR THALASSEMIA IN KERMAN-IRAN. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 3(1), 30-34. SID. https://sid.ir/paper/296742/en

    Vancouver: Copy

    VAHIDI A.A., VARES VAZIRIAN M., SHAMS ALDINI A.. DETERMINATION OF HEPATITIS B SURFACE ANTIBODY TITER IN VACCINATED CHILDREN WITH MAJOR THALASSEMIA IN KERMAN-IRAN. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2006;3(1):30-34. Available from: https://sid.ir/paper/296742/en

    IEEE: Copy

    A.A. VAHIDI, M. VARES VAZIRIAN, and A. SHAMS ALDINI, “DETERMINATION OF HEPATITIS B SURFACE ANTIBODY TITER IN VACCINATED CHILDREN WITH MAJOR THALASSEMIA IN KERMAN-IRAN,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 3, no. 1, pp. 30–34, 2006, [Online]. Available: https://sid.ir/paper/296742/en

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