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Information Journal Paper

Title

ANTI-STREPTOKINASE ANTIBODY DETECTION BEFORE AND IMMEDIATELY AFTER STREPTOKINASE THERAPY IN PATIENTS WITH MYOCARDIAL INFARCTION

Pages

  66-69

Abstract

 Background: MYOCARDIAL INFARCTION is one of the most common and serious diseases resulting from coronary artery occlusion (obstruction) and major reduction in blood flow which occurs following rupture of atherosclerotic plaque or narrowing of coronary arteries. STREPTOKINASE as a thrombolytic is considered the first and most important therapeutic intervention for reperfusion following MYOCARDIAL INFARCTION (MI) in most countries including Iran. Our previous study showed that, the prevalence of high antibody titers against STREPTOKINASE was 13.5% in the studied population from Iran, which was 2.5 times more common than data from other studies.Objective: To evaluate anti-STREPTOKINASE antibody titers before and immediately after STREPTOKINASE administration and its relation to reperfusion therapy success rates.Methods: A total of 200 patients with acute MYOCARDIAL INFARCTION were selected. Antibodies against STREPTOKINASE were measured before and 2 days after administration of STREPTOKINASE. At admission, before STREPTOKINASE administration and every hour after STREPTOKINASE administration, for 3 consecutive hours, an ECG was taken from each participant and the changes were evaluated in relation to antibody levels.Results: Out of 200 patients, 42 (21%) had high levels of antibody titer. Out of these 42 patients, 13 (6.5%) still had measurable levels of antiSTREPTOKINASE antibody after STREPTOKINASE administration. Conclusion: With respect to the importance of reperfusion in acute MYOCARDIAL INFARCTION, our results show the ability of the anti-STREPTOKINASE antibody to neutralize effects of STREPTOKINASE. Hence, measurement of the serum levels of anti-STREPTOKINASE antibody is recommended before STREPTOKINASE administration.    

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    • Cite

    APA: Copy

    SHEMIRANI, H., & REZAEI, A.. (2006). ANTI-STREPTOKINASE ANTIBODY DETECTION BEFORE AND IMMEDIATELY AFTER STREPTOKINASE THERAPY IN PATIENTS WITH MYOCARDIAL INFARCTION. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 3(2), 66-69. SID. https://sid.ir/paper/296750/en

    Vancouver: Copy

    SHEMIRANI H., REZAEI A.. ANTI-STREPTOKINASE ANTIBODY DETECTION BEFORE AND IMMEDIATELY AFTER STREPTOKINASE THERAPY IN PATIENTS WITH MYOCARDIAL INFARCTION. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2006;3(2):66-69. Available from: https://sid.ir/paper/296750/en

    IEEE: Copy

    H. SHEMIRANI, and A. REZAEI, “ANTI-STREPTOKINASE ANTIBODY DETECTION BEFORE AND IMMEDIATELY AFTER STREPTOKINASE THERAPY IN PATIENTS WITH MYOCARDIAL INFARCTION,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 3, no. 2, pp. 66–69, 2006, [Online]. Available: https://sid.ir/paper/296750/en

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