KILLER CELL IMMUNOGLOBULIN -LIKE RECEPTORS INFLUENCE THE INNATE AND ADAPTIVE IMMUNE RESPONSES

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RAJALINGAM R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Iranian Journal of Immunology Year:2007 | Volume:4 | Issue:2 Page(s): 61-78

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Information Journal Paper

Title

KILLER CELL IMMUNOGLOBULIN -LIKE RECEPTORS INFLUENCE THE INNATE AND ADAPTIVE IMMUNE RESPONSES

Author(s)

RAJALINGAM R. | Issue Writer Certificate

Keywords

NK CELLS

INNATE IMMUNITY

HLA

KIR

POLYMORPHISM

Abstract

Natural killer (NK) cells are a subset of lymphocytes which play a crucial role in early innate immune response against infection and tumor transformation. Furthermore, they secrete interferon-g (IFN-g) and tumor necrosis factor (TNF) prompting adaptive immunity. NK CELLS distinguish the unhealthy cells from the healthy ones through an array of cell-surface receptors. Human NK CELLS use inhibitory and activating killer cell Ig-like receptors (KIR) as primary probe to discriminate between healthy and unhealthy cells. The inhibitory KIRs recognize HLA class I molecules and trigger signals that stop NK killing. The activating KIRs are believed to recognize the determinants associated with infections and tumors, and trigger signals that activate NK killing. Therefore, the effector function of a given NK cell depends upon the receptors that it expresses and ligands that it recognizes on the targets. Genes encoding KIRs and HLA ligands are located on different chromosomes, and vary in number and type. The independent segregation of KIR and HLA genes results in variable KIR-HLA combinations in individuals, which may determine the individual’s immunity and susceptibility to disease.

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APA: Copy

RAJALINGAM, R.. (2007). KILLER CELL IMMUNOGLOBULIN -LIKE RECEPTORS INFLUENCE THE INNATE AND ADAPTIVE IMMUNE RESPONSES. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 4(2), 61-78. SID. https://sid.ir/paper/296783/en

Vancouver: Copy

RAJALINGAM R.. KILLER CELL IMMUNOGLOBULIN -LIKE RECEPTORS INFLUENCE THE INNATE AND ADAPTIVE IMMUNE RESPONSES. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2007;4(2):61-78. Available from: https://sid.ir/paper/296783/en

IEEE: Copy

R. RAJALINGAM, “KILLER CELL IMMUNOGLOBULIN -LIKE RECEPTORS INFLUENCE THE INNATE AND ADAPTIVE IMMUNE RESPONSES,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 4, no. 2, pp. 61–78, 2007, [Online]. Available: https://sid.ir/paper/296783/en

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