SERUM CYTOKINES PROFILES IN IRANIAN PATIENTS WITH PREECLAMPSIA

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MANSOURI M.; AKBARI F.; VODJGANI M.; MAHBOUDI F.; KALANTAR F.; MIRAHMADIAN M.

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Journal Paper

Paper Information

Journal: Iranian Journal of Immunology Year:2007 | Volume:4 | Issue:3 Page(s): 179-185

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Title

SERUM CYTOKINES PROFILES IN IRANIAN PATIENTS WITH PREECLAMPSIA

Author(s)

Keywords

PREECLAMPSIA

CYTOKINES

ELISA

Abstract

Background: PREECLAMPSIA is a major cause of mortality and morbidity and is also a leading cause of preterm birth and intrauterine growth retardation. Several studies have reported abnormal levels of CYTOKINES in women with PREECLAMPSIA. Objectives: To detect serum levels of various CYTOKINES in pregnant women with and without PREECLAMPSIA in the third trimester of pregnancy. Methods: Thirty patients with PREECLAMPSIA and thirty normal pregnant women were enrolled in the study. Blood samples were taken and serum levels of IFN g, IL-12p70, IL-18, IL-15, IL-4 and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA). Results: Preeclamptic women had significantly increased levels of circulating IL-12p70 (p<0.05), IL-18 (p< 0.001), IL-4 (p<0.001), IL-15 (p<0.05) and IFN g (p<0.001). By contrast, circulating levels of IL-10 were not significantly different between the two groups. Conclusions: The present study supports the hypothesis of altered immune response in PREECLAMPSIA and suggest that dysregulation of cytokine expression occurs in PREECLAMPSIA with increased levels of IFN g, IL-12p70, IL-15, IL-18 and IL-4.

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RELATIONSHIP BETWEEN MIGRAINE AND HYPERTENSIVE DISORDERS OF PREGNANCY

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APA: Copy

MANSOURI, M., AKBARI, F., VODJGANI, M., MAHBOUDI, F., KALANTAR, F., & MIRAHMADIAN, M.. (2007). SERUM CYTOKINES PROFILES IN IRANIAN PATIENTS WITH PREECLAMPSIA. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 4(3), 179-185. SID. https://sid.ir/paper/296788/en

Vancouver: Copy

MANSOURI M., AKBARI F., VODJGANI M., MAHBOUDI F., KALANTAR F., MIRAHMADIAN M.. SERUM CYTOKINES PROFILES IN IRANIAN PATIENTS WITH PREECLAMPSIA. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2007;4(3):179-185. Available from: https://sid.ir/paper/296788/en

IEEE: Copy

M. MANSOURI, F. AKBARI, M. VODJGANI, F. MAHBOUDI, F. KALANTAR, and M. MIRAHMADIAN, “SERUM CYTOKINES PROFILES IN IRANIAN PATIENTS WITH PREECLAMPSIA,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 4, no. 3, pp. 179–185, 2007, [Online]. Available: https://sid.ir/paper/296788/en

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