مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

LISTERIA MONOCYTOGENES ACTIVATED DENDRITIC CELL BASED VACCINE FOR PREVENTION OF EXPERIMENTAL TUMOR IN MICE

Pages

  36-44

Abstract

 Background: The use of DENDRITIC CELLS (DCs) as a cellular adjuvant provides a promising approach in IMMUNOTHERAPY of CANCER. It has been demonstrated that LISTERIA MONOCYTOGENES activated DCs pulsed ex vivo with tumor antigens trigger a systemic Th1-biased specific immune response and a single dose of this vaccine will cause a consider-able anti tumor immunity.Objective: The present study was designed to evaluate the ability of multiple doses of tumor antigen-pulsed DCs, matured in the presence of LISTERIA MONOCYTOGENES components in induction of a potent anti-tumor response and the prevention of tumor formation in an experimental model.Methods: Bone-marrow de-rived DCs (BMDCs) were cultured in the presence of GM-CSF and IL-4. After 5 days, tumor lysates with/without LISTERIA MONOCYTOGENES lysate were added to the culture media for another 2 days. Mice received mature and tumor antigen pulsed DENDRITIC CELLS subcutaneously in 3 groups. Tumor growth was monitored and two weeks after IMMUNOTHERAPY, cytotoxic activity of CD8+ T cells was evaluated in different groups.Results: According to the findings, repeated doses of vaccine did not lead to a significant increase in the activity of cytotoxic T cells and decreased tumor growth of immunized animals.Conclusion: The current study suggests that increased doses of vaccine do not have sufficient efficiency for prevention of tumor induction. Generation of T regulatory responses upon repeated doses of such vaccines should be considered in future investigations

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    APA: Copy

    KHAMISABADI, MASOUMEH, ARAB, S., MOTAMEDI, MASOUMEH, KHANSARI, NEMAT ELAH, MOAZENI, S.M., GHEFLATI, ZAHRA, & HAJATI, JAMSHID. (2008). LISTERIA MONOCYTOGENES ACTIVATED DENDRITIC CELL BASED VACCINE FOR PREVENTION OF EXPERIMENTAL TUMOR IN MICE. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 5(1), 36-44. SID. https://sid.ir/paper/296807/en

    Vancouver: Copy

    KHAMISABADI MASOUMEH, ARAB S., MOTAMEDI MASOUMEH, KHANSARI NEMAT ELAH, MOAZENI S.M., GHEFLATI ZAHRA, HAJATI JAMSHID. LISTERIA MONOCYTOGENES ACTIVATED DENDRITIC CELL BASED VACCINE FOR PREVENTION OF EXPERIMENTAL TUMOR IN MICE. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2008;5(1):36-44. Available from: https://sid.ir/paper/296807/en

    IEEE: Copy

    MASOUMEH KHAMISABADI, S. ARAB, MASOUMEH MOTAMEDI, NEMAT ELAH KHANSARI, S.M. MOAZENI, ZAHRA GHEFLATI, and JAMSHID HAJATI, “LISTERIA MONOCYTOGENES ACTIVATED DENDRITIC CELL BASED VACCINE FOR PREVENTION OF EXPERIMENTAL TUMOR IN MICE,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 5, no. 1, pp. 36–44, 2008, [Online]. Available: https://sid.ir/paper/296807/en

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