IMMUNOLOGIC BASIS AND IMMUNOPROPHYLAXIS OF RHD INDUCED HEMOLYTIC DISEASE OF THE NEWBORN (HDN)

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PAYAM KHAJA PASHA R.; SHOKRI F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Iranian Journal of Immunology Year:2008 | Volume:5 | Issue:4 Page(s): 189-200

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Information Journal Paper

Title

IMMUNOLOGIC BASIS AND IMMUNOPROPHYLAXIS OF RHD INDUCED HEMOLYTIC DISEASE OF THE NEWBORN (HDN)

Author(s)

PAYAM KHAJA PASHA R. | SHOKRI F. | Issue Writer Certificate

Keywords

ANTI-D IMMUNOGLOBULIN

D ANTIGEN

HEMOLYTIC DISEASE OF THE NEWBORN (HDN)

MONOCLONAL ANTI-D

RH BLOOD GROUP SYSTEM

Abstract

RhD antigen is the most immunogenic and clinically significant antigen of red blood cells after ABO system. It has historically been associated with hemolytic disease of the newborn (HDN) which is now routinely prevented by the administration of polyclonal ANTI-D IMMUNOGLOBULIN. This management of HDN has proven to be one of the most successful cases of prophylactic treatment based on antibody mediated immune sup-pression (AMIS). Despite the increasing efficiency of treatment, the mechanism of ac-tion of anti-D is not completely defined. There is a widespread interest in obtaining a reliable therapeutic MONOCLONAL ANTI-D, due to difficulty of maintaining a pool of high titer volunteer donors for plasma collection and also increasing demand for antenatal prophylaxis and safety issues with plasma derived products. Candidate MONOCLONAL ANTI-D preparations should demonstrate appropriate functionality in both in vitro and in vivo assays comparable to polyclonal ANTI-D IMMUNOGLOBULIN. These criteria are reviewed in addition to the factors regulating development of D specific immune response in D negative individuals and its suppression in HDN prophylaxis.

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APA: Copy

PAYAM KHAJA PASHA, R., & SHOKRI, F.. (2008). IMMUNOLOGIC BASIS AND IMMUNOPROPHYLAXIS OF RHD INDUCED HEMOLYTIC DISEASE OF THE NEWBORN (HDN). IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 5(4), 189-200. SID. https://sid.ir/paper/296824/en

Vancouver: Copy

PAYAM KHAJA PASHA R., SHOKRI F.. IMMUNOLOGIC BASIS AND IMMUNOPROPHYLAXIS OF RHD INDUCED HEMOLYTIC DISEASE OF THE NEWBORN (HDN). IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2008;5(4):189-200. Available from: https://sid.ir/paper/296824/en

IEEE: Copy

R. PAYAM KHAJA PASHA, and F. SHOKRI, “IMMUNOLOGIC BASIS AND IMMUNOPROPHYLAXIS OF RHD INDUCED HEMOLYTIC DISEASE OF THE NEWBORN (HDN),” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 5, no. 4, pp. 189–200, 2008, [Online]. Available: https://sid.ir/paper/296824/en

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