THE EFFECT OF BETA INTERFERON ON DENDRITIC CELLS AND CYTOKINE SYNTHESIS BY CD4+ T CELLS

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ABEDIAN KENARI S.; SHAKER D.; ABEDIAN F.; MIRABI A.M.

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Journal Paper

Paper Information

Journal: Iranian Journal of Immunology Year:2009 | Volume:6 | Issue:2 Page(s): 61-66

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Title

THE EFFECT OF BETA INTERFERON ON DENDRITIC CELLS AND CYTOKINE SYNTHESIS BY CD4+ T CELLS

Author(s)

ABEDIAN KENARI S. | SHAKER D. | ABEDIAN F. | MIRABI A.M. | Issue Writer Certificate

Keywords

DENDRITIC CELLS

INTERFERON-BETA

INTERLEUKIN-17

Abstract

Background: DENDRITIC CELLS (DC) are a key regulator of the immune response, and interferon- beta (IFN-b) is considered an immunomodulatory molecule for DC.Objective: The purpose of this study was to evaluate the ability of IFN-b treated DC to induce cytokine secretion by CD4+ T cells.Methods: DENDRITIC CELLS were generated from blood monocyte’s with granulocyte-monocyte colony-stimulating factor and interleukin-4 with or without IFN-b. We analyzed the production of CD4+ T helper cytokines (IL-17, IFN- g and IL-10) in the supernatant of the dendritic cell-T cell co- cultures by ELISA. We also studied the effects of HLA-G and co stimulatory molecules on immature and mature DC.Results: IFN-g and IL-17 decreased significantly in the presence of HLA-Gbearing DC compared to control cultures (p<0.05).Conclusion: Using the mixed leukocyte reaction, we found that DC treated with IFN-b mediated the inhibition of T cell activation via cytokine production. We conclude that this is important for preventing over activation of the immune system.

Cites

HLA-G5 AND G7 ISOFORMS IN PREGNANT WOMEN (BRIEF COMMUNICATION)

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APA: Copy

ABEDIAN KENARI, S., SHAKER, D., ABEDIAN, F., & MIRABI, A.M.. (2009). THE EFFECT OF BETA INTERFERON ON DENDRITIC CELLS AND CYTOKINE SYNTHESIS BY CD4⁺ T CELLS. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 6(2), 61-66. SID. https://sid.ir/paper/296841/en

Vancouver: Copy

ABEDIAN KENARI S., SHAKER D., ABEDIAN F., MIRABI A.M.. THE EFFECT OF BETA INTERFERON ON DENDRITIC CELLS AND CYTOKINE SYNTHESIS BY CD4⁺ T CELLS. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2009;6(2):61-66. Available from: https://sid.ir/paper/296841/en

IEEE: Copy

S. ABEDIAN KENARI, D. SHAKER, F. ABEDIAN, and A.M. MIRABI, “THE EFFECT OF BETA INTERFERON ON DENDRITIC CELLS AND CYTOKINE SYNTHESIS BY CD4⁺ T CELLS,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 6, no. 2, pp. 61–66, 2009, [Online]. Available: https://sid.ir/paper/296841/en

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