Prognostic Value of HLA-G in Malignant Liver and Pancreas Lesions

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Khodabandeh Shahraki Parisa; Zare yasmin; AZARPIRA NEGAR; HOSSEINZADEH MASSOOD; FARJADIAN SHIRIN

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Journal: Iranian Journal of Immunology Year:2018 | Volume:15 | Issue:1 Page(s): 28-37

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Title

Prognostic Value of HLA-G in Malignant Liver and Pancreas Lesions

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Keywords

Human Leukocyte Antigen-G

Hepatocellular Carcinoma

Hepatitis B Virus

Pancreatic Adenocarcinoma

Abstract

Background: Human leukocyte antigen (HLA)-G is a nonclassical HLA class I molecule with modulatory effects on NK and T cells. Because HLA-G expression is frequently detected in different solid tumors, it may be involved in tumor immune evasion. Objective: This study was designed to elucidate the prognostic value of HLAG in Hepatocellular Carcinoma (HCC) and Pancreatic Adenocarcinoma (PADC). The influence of Hepatitis B Virus (HBV) infection on HLA-G expression was also evaluated in patients with HCC. Methods: HLA-G expression was investigated in tumor tissues from patients with HCC (n=74) or PADC (n=42) with immunohistochemical techniques. The presence of HBV genome was also examined in HCC tumor tissues by PCR. Results: HLA-G expression was detected in 66% of PADC and in 31% of HCC samples. In contrast to HCC, HLA-G overexpression was associated with advanced stages and grades in PADC. HBV genome was detected in 31% of HCC samples but we found no correlation between HLA-G expression and the presence of HBV genome in these tumors. Conclusion: Our findings showed that HLA-G overexpression in tumor tissue correlated with poor prognosis in PADC. HLA-G expression is apparently affected by the patient’ s genetic background and other epigenetic factors rather than by HBV infection.

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APA: Copy

Khodabandeh Shahraki, Parisa, Zare, yasmin, AZARPIRA, NEGAR, HOSSEINZADEH, MASSOOD, & FARJADIAN, SHIRIN. (2018). Prognostic Value of HLA-G in Malignant Liver and Pancreas Lesions. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 15(1), 28-37. SID. https://sid.ir/paper/296911/en

Vancouver: Copy

Khodabandeh Shahraki Parisa, Zare yasmin, AZARPIRA NEGAR, HOSSEINZADEH MASSOOD, FARJADIAN SHIRIN. Prognostic Value of HLA-G in Malignant Liver and Pancreas Lesions. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2018;15(1):28-37. Available from: https://sid.ir/paper/296911/en

IEEE: Copy

Parisa Khodabandeh Shahraki, yasmin Zare, NEGAR AZARPIRA, MASSOOD HOSSEINZADEH, and SHIRIN FARJADIAN, “Prognostic Value of HLA-G in Malignant Liver and Pancreas Lesions,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 15, no. 1, pp. 28–37, 2018, [Online]. Available: https://sid.ir/paper/296911/en

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