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Information Journal Paper

Title

Expression of IGF-1, IL-27 and IL-35 Receptors in Adjuvant Induced Rheumatoid Arthritis Model

Pages

  14-27

Abstract

 Background: IGF-1 and certain other cytokines have been shown to exert inflammatory/anti-inflammatory roles in chronic joint diseases. Objective: To assess the effect of IGF-1, IL-27 and IL-35, their interaction and their Receptor Expression in a rheumatoid arthritis model. Methods: Freund’ s adjuvant-induced Chronic Joint Inflammation was operated on 160 male rats. Animals were divided into Histopathology and Receptor Expression groups, each composed of 10 subgroups including; control, vehicle, IGF-1, IL-27, IL-35, their antagonists, IGF-1+IL-27 antagonist and IGF-1+IL-35 antagonist. After two weeks, vehicle or agonist/antagonists were injected into the joint space every other day until day 28 where joint Histopathology was performed. The expression of IGF-1, IL-27 and IL-35 receptors were assessed by western blot analysis. Results: IGF-1 did not show pro-or anti-inflammatory functions; endogenous IL-27 and IL-35, on the other hand, exerted inflammatory effects. IL-27 and IL-35 antagonists exerted the highest anti-inflammatory effects. The total inflammation scores were 0. 55 ± 0. 06, 4. 63 ± 0. 40, 3. 63 ± 0. 60, 2. 50 ± 0. 38 and 1. 63 ± 0. 40 regarding control, vehicle, IGF-1 Ant., IL-27 Ant. and IL-35Ant., respectively. IGF-1 Receptor Expression was reduced in Chronic Joint Inflammation and all three antagonists augmented the IGF-1 Receptor Expression. IL-27 and IL-35 receptors were up-regulated by Chronic Joint Inflammation. Conclusion: Overall, the results demonstrated the pro-inflammatory role of endogenous IL-27 and IL-35 along with the over expression of their receptors in Chronic Joint Inflammation. IL-27 and IL-35 antagonists exerted the most antiinflammatory effects and increased IGF-1 Receptor Expression. These two antagonists may be potential agents for new treatment strategies in chronic joint inflammatory diseases.

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    APA: Copy

    ABDI, ELHAM, NAJAFIPOUR, HAMID, JOUKAR, SIYAVASH, DABIRI, SHAHRIAR, Esmaeli Mahani, Saeed, ABBASLOO, ELHAM, Houshmandi, nasrin, & Afsharipour, Abbas. (2018). Expression of IGF-1, IL-27 and IL-35 Receptors in Adjuvant Induced Rheumatoid Arthritis Model. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 15(1), 14-27. SID. https://sid.ir/paper/296915/en

    Vancouver: Copy

    ABDI ELHAM, NAJAFIPOUR HAMID, JOUKAR SIYAVASH, DABIRI SHAHRIAR, Esmaeli Mahani Saeed, ABBASLOO ELHAM, Houshmandi nasrin, Afsharipour Abbas. Expression of IGF-1, IL-27 and IL-35 Receptors in Adjuvant Induced Rheumatoid Arthritis Model. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2018;15(1):14-27. Available from: https://sid.ir/paper/296915/en

    IEEE: Copy

    ELHAM ABDI, HAMID NAJAFIPOUR, SIYAVASH JOUKAR, SHAHRIAR DABIRI, Saeed Esmaeli Mahani, ELHAM ABBASLOO, nasrin Houshmandi, and Abbas Afsharipour, “Expression of IGF-1, IL-27 and IL-35 Receptors in Adjuvant Induced Rheumatoid Arthritis Model,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 15, no. 1, pp. 14–27, 2018, [Online]. Available: https://sid.ir/paper/296915/en

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