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Information Journal Paper

Title

Roles of Dermcidin, Salusin-α , Salusin-β and TNF-α in the Pathogenesis of Human Brucellosis

Pages

  182-189

Abstract

 Background: Brucella spp. are facultative intracellular pathogens that can cause chronic infections in many tissues and organs. Objectives: To investigate serum Dermcidin, Salusin-Alpha, Salusin-Beta and TNF-Alpha levels and their correlation with each other in patients with acute Brucellosis. Methods: From 50 patients hospitalized upon diagnosis of acute Brucellosis, blood samples were collected and Dermcidin, Salusin-Alpha, Salusin-Beta and TNF-Alpha levels in serum samples were measured using an ELISA assay. The control group included 40 volunteers. Results: Brucellosis group had significantly lower plasma Dermcidin, Salusin-Alpha, Salusin-Beta levels compared to the healthy control group (respectively p: 0. 008, p<0. 001, p<0. 001). Moreover, Brucellosis group had significantly higher plasma TNF-Alpha levels comparisons with the controls (p=0. 002). In the examination of the correlation between TNF-Alpha and Dermcidin, Salusin-Alpha and Salusin-Beta in the Brucellosis group, only a negative correlation was found between Salusin-Beta and TNF-Alpha. In the control group, there was a positive and statistically significant correlation between Salusin-Beta and TNF-Alpha. Conclusion: Dermcidin, Salusin-Alpha, and, particularly Salusin-Beta levels are important in Brucella pathogenesis. The paradoxical correlation between TNF-Alpha and Salusin-Beta in patients with Brucellosis and control group is remarkable. However, there is a need for extensive studies conducted with more patients to further elucidate this topic.

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    APA: Copy

    Tartar, Ayse Sagmak, Balin, Safak ozer, Akbulut, Ayhan, Yardim, Meltem, & Aydin, Suleyman. (2019). Roles of Dermcidin, Salusin-α , Salusin-β and TNF-α in the Pathogenesis of Human Brucellosis. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 16(2), 182-189. SID. https://sid.ir/paper/296919/en

    Vancouver: Copy

    Tartar Ayse Sagmak, Balin Safak ozer, Akbulut Ayhan, Yardim Meltem, Aydin Suleyman. Roles of Dermcidin, Salusin-α , Salusin-β and TNF-α in the Pathogenesis of Human Brucellosis. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2019;16(2):182-189. Available from: https://sid.ir/paper/296919/en

    IEEE: Copy

    Ayse Sagmak Tartar, Safak ozer Balin, Ayhan Akbulut, Meltem Yardim, and Suleyman Aydin, “Roles of Dermcidin, Salusin-α , Salusin-β and TNF-α in the Pathogenesis of Human Brucellosis,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 16, no. 2, pp. 182–189, 2019, [Online]. Available: https://sid.ir/paper/296919/en

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